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Home › Research › Topics › precursor

precursor

1,346 studies tagged precursor, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,346 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Predictive utility of apolipoprotein E genotype for Alzheimer disease in outpatients with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Archives of neurology 2005-06-01 Genetics

    APOE epsilon4 carrier status was associated with conversion to AD in older outpatients after controlling for known demographic and clinical risk factors, and APOE epsilon4 homozygosity was associated with increased risk of conversion to AD.

  2. APOE genotype, cholesterol level, lipid-lowering treatment, and dementia: the Three-City Study

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 2005-05-01 Genetics

    This observational study provides further evidence that lipid-lowering agents are associated with decreased risk of dementia, whereas hyperlipidemia is associated with increased odds for non-Alzheimer-disease-type dementia.

  3. Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2005-05-01 Caregiving

    Epidemiological studies suggest that individuals with greater education or more cognitively demanding occupations have diminished risk of developing dementia.

  4. The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neurology 2005-05-01 TREM2 and immune genetics

    Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), or Nasu-Hakola disease, is a presenile dementia associated with loss of myelin, basal ganglia calcification, and bone cysts.

  5. Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Neurobiology of aging 2005-04-15 Biomarkers

    We determined whether oxidative stress is an early event in the pathogenesis of sporadic Alzheimer disease (AD), and correlated oxidative stress with neuropsychological functions and neurofibrillary pathology in AD and mild cognitive impairment (MCI).

  6. Episodic-like memory deficits in the APPswe/PS1dE9 mouse model of Alzheimer's disease: relationships to beta-amyloid deposition and neurotransmitter abnormalities

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurobiology of disease 2005-04-01 Risk genes beyond APOE

    Transgenic mice made by crossing animals expressing mutant amyloid precursor protein (APPswe) to mutant presenilin 1 (PS1dE9) allow for incremental increases in Abeta42 production and provide a model of Alzheimer-type amyloidosis.

  7. Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2005-03-29 Disease mechanisms

    Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and lipoxidation could contribute to Alzheimer disease pathogenesis.

  8. The apolipoprotein E epsilon4 allele increases the odds of chronic cerebral infarction [corrected] detected at autopsy in older persons

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Stroke 2005-03-17 Genetics

    Subjects included 96 males and 118 females with a mean age at death of 86 years (SD, 7).

  9. A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2005-03-01 Genetics

    Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of Alzheimer's disease (AD).

  10. Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurobiology of disease 2005-02-01 Inflammation and the immune system

    The role of microglia recruited from bone marrow (BM) into the CNS during the progression of Alzheimer's disease (AD) is poorly understood.

  11. fMRI evidence of compensatory mechanisms in older adults at genetic risk for Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Neurology 2005-02-01 Genetics

    The results suggest that brain response differences are not due to poorer general memory abilities, differential atrophy, or brain response during control conditions, but instead appear to be directly influenced by APOE genotype.

  12. Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. PLoS medicine 2005-01-11 Risk genes beyond APOE

    Recent evidence suggests that statin use may be associated with a decreased risk for Alzheimer disease, although the mechanisms underlying this apparent risk reduction are poorly understood.

  13. Cerebral glucose metabolism in patients with AD and different APOE genotypes

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 2005-01-01 Genetics

    A generally similar pattern of cerebral hypometabolism was detected in APOE epsilon4-positive and -negative patients with Alzheimer disease.

  14. Cholinergic-serotonergic imbalance contributes to cognitive and behavioral symptoms in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Neuropsychologia 2005-01-01 Cognitive tests and assessment

    Neuropsychiatric symptoms seen in Alzheimer's disease (AD) are not simply a consequence of neurodegeneration, but probably result from differential neurotransmitter alterations, which some patients are more at risk of than others.

  15. Human-like rodent amyloid-beta-peptide determines Alzheimer pathology in aged wild-type Octodon degu

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurobiology of aging 2004-12-10 Risk genes beyond APOE

    It is generally accepted that human Alzheimer's disease (AD) neuropathology markers are completely absent in rodent brains.

  16. MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurology 2004-12-01 Genetics

    After 1 year, 8 of 37 patients with MCI converted to AD (22%).

  17. Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurobiology of aging 2004-11-25 Biomarkers

    Dietary influences on Alzheimer disease (AD) are gaining recognition.

  18. Aging-related increase in oxidative stress correlates with developmental pattern of beta-secretase activity and beta-amyloid plaque formation in transgenic Tg2576 mice with Alzheimer-like pathology

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2004-11-01 Risk genes beyond APOE

    The molecular mechanisms of beta-amyloidogenesis in sporadic Alzheimer's disease are still poorly understood.

  19. Amyloid beta-peptide(1-42) contributes to the oxidative stress and neurodegeneration found in Alzheimer disease brain

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Brain pathology (Zurich, Switzerland) 2004-10-01 Risk genes beyond APOE

    Oxidative stress is extensive in Alzheimer disease (AD) brain.

  20. Inhaled anesthetic enhancement of amyloid-beta oligomerization and cytotoxicity

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Anesthesiology 2004-09-01 Risk factors

    Inhaled anesthetics enhance oligomerization and cytotoxicity of Alzheimer disease-associated peptides.

  21. Neuronal expression of myeloperoxidase is increased in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of neurochemistry 2004-08-01 Inflammation and the immune system

    Myeloperoxidase, a heme protein expressed by professional phagocytic cells, generates an array of oxidants which are proposed to contribute to tissue damage during inflammation.

  22. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuropathology and experimental neurology 2004-08-01 Risk genes beyond APOE

    The neuronal lysosomal system is a major degradative pathway, induced by cell stress and closely linked to Alzheimer disease (AD) and other neurodegenerative diseases.

  23. Analysis of European mitochondrial haplogroups with Alzheimer disease risk

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neuroscience letters 2004-07-01 Genetics

    We examined the association of mtDNA variation with Alzheimer disease (AD) risk in Caucasians (989 cases and 328 controls) testing the effect of individual haplogroups and single nucleotide polymorphisms (SNPs).

  24. Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Experimental neurology 2004-07-01 Genetics

    We compared lesions in elderly transgenic (tg) mice carrying the Swedish double mutation KM670/671NL with lesions in Alzheimer disease (AD) by histochemical and immunohistochemical techniques.

  25. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Nature medicine 2004-06-13 Genetics

    We have previously shown that apolipoprotein E (Apoe) promotes the formation of amyloid in brain and that astrocyte-specific expression of APOE markedly affects the deposition of amyloid-beta peptides (Abeta) in a mouse model of Alzheimer disease.

  26. APOE-[epsilon]2 allele associated with higher prevalence of sporadic Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2004-06-01 Genetics

    Unlike Alzheimer disease, for which the APOE-epsilon4 allele increases the prevalence and the APOE-epsilon2 allele is protective, the authors' analysis shows the APOE-epsilon2 allele, but not the APOE-epsilon4 allele, to be positively associated with sporadic Parkinson disease.

  27. APOE epsilon4 allele is associated with reduced cerebrospinal fluid levels of Abeta42

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2004-06-01 Genetics

    The epsilon4 allele of APOE is a risk factor for Alzheimer disease (AD).

  28. Apolipoprotein E controls the risk and age at onset of Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2004-06-01 Genetics

    The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.

  29. Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2004-06-01 Genetics

    The epsilon4 allele does not predict cholinergic decline in AD.

  30. Longitudinal changes in cognition and behavior in asymptomatic carriers of the APOE e4 allele

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 2004-06-01 Genetics

    Memory declined in APOE e4 carriers before the symptomatic presentation of MCI in a cohort whose mean age was 60 years over a median period of 33 months.

  31. Biological inorganic and bioinorganic chemistry of neurodegeneration based on prion and Alzheimer diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Dalton transactions (Cambridge, England : 2003) 2004-05-11 Risk genes beyond APOE

    A change of the prion protein conformation results in a class of neurodegenerative diseases called the transmissible spongiform encephalopathies (like mad cow and Creutzfeld-Jakob diseases).

  32. A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Annals of neurology 2004-05-01 Disease mechanisms

    Familial forms of frontotemporal dementia (FTD) with tauopathy are mostly caused by mutations in the gene encoding the microtubule-associated protein tau (MAPT).

  33. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuropathology and experimental neurology 2004-05-01 Risk genes beyond APOE

    In Alzheimer disease (AD) patients, early memory dysfunction is associated with glucose hypometabolism and neuronal loss in the hippocampus.

  34. Amyloid beta-peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of peptide science : an official publication of the European Peptide Society 2004-05-01 Risk genes beyond APOE

    The extracellular accumulation of amyloid-beta (Abeta) in neuritic plaques is one of the characteristic hallmarks of Alzheimer's disease (AD), a progressive dementing neurodegenerative disorder of the elderly.

  35. Apolipoprotein E epsilon4 count affects age at onset of Alzheimer disease, but not lifetime susceptibility: The Cache County Study

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Archives of general psychiatry 2004-05-01 Genetics

    The APOE epsilon4 allele acts as a potent risk factor for AD by accelerating onset.

  36. Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neurobiology of aging 2004-05-01 Biomarkers

    Amyloid plaques appear early during Alzheimer's disease (AD), and their development is intimately linked to activated astrocytes and microglia.

  37. Dendrite and dendritic spine alterations in Alzheimer models

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neurocytology 2004-05-01 Risk genes beyond APOE

    Synaptic damage and loss are factors that affect the degree of dementia experienced in Alzheimer disease (AD) patients.

  38. The microglial phagocytic role with specific plaque types in the Alzheimer disease brain

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neurobiology of aging 2004-05-01 Inflammation and the immune system

    Alzheimer disease (AD) involves glial inflammation associated with amyloid plaques.

  39. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2004-04-01 Risk genes beyond APOE

    Beta-amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology.

  40. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. European journal of pharmacology 2004-04-01 Risk genes beyond APOE

    Nosologically, Alzheimer disease is not a single disorder in spite of a common clinical phenotype.

  41. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neurology 2004-03-01 Biomarkers

    These data support distinct processes in the initiation and progression of AD pathology within the temporal cortex: Deposition of Abeta reaches a "ceiling" early in the disease process, whereas NFT formation, synaptic loss, and gliosis continue throughout the course of the illness.

  42. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Archives of neurology 2004-03-01 How common it is

    Longitudinal clinicopathologic cohort study.

  43. Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Archives of neurology 2004-03-01 Treatments

    This study questions the effect of statins on the processing of amyloid precursor protein in humans.

  44. Binding sites of amyloid beta-peptide in cell plasma membrane and implications for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Current protein & peptide science 2004-02-01 Risk genes beyond APOE

    The binding of amyloid beta peptides (Abeta) to plasma membranes appears to be a promising point of intervention in the events leading to the development of Alzheimer's disease (AD).

  45. Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neurology 2004-02-01 Risk genes beyond APOE

    Amyloid precursor protein (APP), ADAM 10, and beta-site-APP cleaving enzyme (BACE) alterations were evaluated in platelets of 31 patients with Alzheimer disease (AD) and 15 age-matched controls.

  46. Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Advances in experimental medicine and biology 2004-01-01 Risk genes beyond APOE

    Alzheimer disease is not a single disorder.

  47. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neuron 2003-12-01 Risk genes beyond APOE

    Converging evidence suggests that the accumulation of cerebral amyloid beta-protein (Abeta) in Alzheimer's disease (AD) reflects an imbalance between the production and degradation of this self-aggregating peptide.

  48. Environmental enrichment exacerbates amyloid plaque formation in a transgenic mouse model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuropathology and experimental neurology 2003-12-01 Risk genes beyond APOE

    Epidemiological studies of Alzheimer patients from a wide variety of ethnic and socioeconomic backgrounds have identified education and occupation as environmental factors that can affect the risk of developing disease.

  49. Increased expression and processing of the Alzheimer amyloid precursor protein in pancreatic cancer may influence cellular proliferation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cancer research 2003-11-01 Risk genes beyond APOE

    Abnormal cleavage of amyloid precursor protein (APP) in the central nervous system has been linked to the development of Alzheimer's disease.

  50. A1 adenosine receptors accumulate in neurodegenerative structures in Alzheimer disease and mediate both amyloid precursor protein processing and tau phosphorylation and translocation

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Brain pathology (Zurich, Switzerland) 2003-10-01 Risk genes beyond APOE

    Immunostaining of adenosine receptors in the hippocampus and cerebral cortex from necropsies of Alzheimer disease (AD) patients shows that there is a change in the pattern of expression and a redistribution of receptors in these brain areas when compared with samples from controls.

From across this tag

9 of the 1,344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts