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Home › Research › Topics › notch

notch

3 studies tagged notch, dated 1999-04-01 to 2003-04-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration 2003-04-18
  2. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish 2002-07-01
  3. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants 1999-04-01

Studies

3 studies carry this tag.

Date range

1999 to 2003

Top journals

  • Annual review of neuroscience 1
  • EMBO reports 1
  • Nature 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of neuroscience 2003-04-18 Risk genes beyond APOE

    Intensive studies of three proteins--Presenilin, Notch, and the amyloid precursor protein (APP)--have led to the recognition of a direct intersection between early development and late-life neurodegeneration.

  2. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. EMBO reports 2002-07-01 Risk genes beyond APOE

    Inhibition of amyloid beta-peptide (Abeta) production by blocking gamma-secretase activity is at present one of the most promising therapeutic strategies to slow progression of Alzheimer's disease pathology. gamma-secretase inhibitors apparently block Abeta generation via interference with presenilin (PS) function.

  3. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature 1999-04-01 Risk genes beyond APOE

    Presenilin proteins have been implicated both in developmental signalling by the cell-surface protein Notch and in the pathogenesis of Alzheimer's disease.

All topic tags with their study counts