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Home › Research › Topics › neurotoxicity

neurotoxicity

8 studies tagged neurotoxicity, dated 1998-05-01 to 2022-04-26. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology 2022-04-26
  2. Reactive Astrocytes Contribute to Alzheimer's Disease-Related Neurotoxicity and Synaptotoxicity in a Neuron-Astrocyte Co-culture Assay 2022-01-21
  3. Comparison of neurotoxicity of different aggregated forms of Aβ40, Aβ42 and Aβ43 in cell cultures 2017-02-16

Studies

8 studies carry this tag.

Date range

1998 to 2022

Top journals

  • Annals of the New York Academy of Sciences 2
  • ACS chemical neuroscience 1
  • Acta neuropathologica 1
  • Frontiers in cellular neuroscience 1
  • Human molecular genetics 1

7 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. APOE4 exacerbates α-synuclein seeding activity and contributes to neurotoxicity in Alzheimer's disease with Lewy body pathology

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Acta neuropathologica 2022-04-26 Genetics

    Approximately half of Alzheimer's disease (AD) brains have concomitant Lewy pathology at autopsy, suggesting that α-synuclein (α-SYN) aggregation is a regulated event in the pathogenesis of AD.

  2. Reactive Astrocytes Contribute to Alzheimer's Disease-Related Neurotoxicity and Synaptotoxicity in a Neuron-Astrocyte Co-culture Assay

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in cellular neuroscience 2022-01-21 Biomarkers

    Pathogenesis of presymptomatic disease stages remains elusive, although studies suggest that the early structural and functional alterations likely occur at neuronal dendritic spines.

  3. Comparison of neurotoxicity of different aggregated forms of Aβ40, Aβ42 and Aβ43 in cell cultures

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of peptide science : an official publication of the European Peptide Society 2017-02-16 Biomarkers

    The abnormal deposition of amyloid-β (Aβ) peptides in the brain is the main neuropathological hallmark of Alzheimer's disease (AD).

  4. Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. ACS chemical neuroscience 2017-01-12 Biomarkers

    The formation of soluble oligomers of amyloid β42 and 40 (Aβ42, Aβ40) is the initial event in the pathogenesis of Alzheimer's disease (AD).

  5. 5-Hydroxymethylation-associated epigenetic modifiers of Alzheimer's disease modulate Tau-induced neurotoxicity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2016-04-09 Genetics

    Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive deterioration of cognitive function.

  6. Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2005-12-12 Genetics

    Apolipoprotein (apo) E4, a 299-aa protein and a major risk factor for Alzheimer's disease, can be cleaved to generate C-terminal-truncated fragments that cause neurotoxicity in vitro and neurodegeneration and behavioral deficits in transgenic mice.

  7. Neurotoxicity and oxidative damage of beta amyloid 1-42 versus beta amyloid 1-40 in the mouse cerebral cortex

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of the New York Academy of Sciences 1999-01-01 Biomarkers

    Senile plaques (SP), a neuropathological hallmark of Alzheimer's disease (AD), are characterized by extracellular accumulations of beta amyloid (A beta).

  8. The impact of gender and estrogen on striatal dopaminergic neurotoxicity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annals of the New York Academy of Sciences 1998-05-01 Biomarkers

    The reproductive properties of estrogen are well established, but it is now evident that this steroid hormone has substantial modulatory capabilities in nonreproductive systems.

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