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molecular
6 studies tagged molecular, dated 1992-10-01 to 2024-10-24. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer's Pathogenesis 2024-10-24
- Alzheimer's Aβ42 and Aβ40 form mixed oligomers with direct molecular interactions 2020-12-01
- Fluid biomarker-based molecular phenotyping of Alzheimer's disease patients in research and clinical settings 2019-07-24
Studies
6 studies carry this tag.
Date range
1992 to 2024
Top journals
- Biochemical and biophysical research communications 1
- Molecular brain 1
- Molecular neurobiology 1
- Neurobiology of aging 1
- Neurochemistry international 1
6 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Alzheimer's disease (AD) is the most common form of dementia around the world (~ 65%).
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Formation of Aβ oligomers and fibrils plays a central role in the pathogenesis of Alzheimer's disease.
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Alzheimer's disease (AD) is very difficult to diagnose on pure clinical grounds, especially in the earlier phases of the disease.
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A major barrier to the effective conduct of clinical trials of new drug candidates against Alzheimer's disease (AD) and to identifying patients for receiving future disease-modifying treatments is the limited capacity of the current health system to find and diagnose patients with early AD pathology.
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The ideal biomarker for Alzheimer's disease (AD) should detect a fundamental feature of neuropathology and be validated in neuropathologically-confirmed cases; it should have a sensitivity >80% for detecting AD and a specificity of >80% for distinguishing other dementias; it should be reliable, reproducible, non-invasive, simple to perform, and inexpensive.
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The pattern of molecular forms of acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) separated by density gradient centrifugation was investigated in the brain and cerebrospinal fluid in Alzheimer's disease (AD), in human embryonic brain and in rat brain after experimental cholinergic deafferentation of the cerebral cortex.