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metals-copper-zinc-and-amyloid
4 studies tagged metals-copper-zinc-and-amyloid, dated 2006-07-01 to 2016-10-17. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Colocalization of cerebral iron with Amyloid beta in Mild Cognitive Impairment 2016-10-17
- Value of serum nonceruloplasmin copper for prediction of mild cognitive impairment conversion to Alzheimer disease 2014-04-14
- Effect of copper intake on CSF parameters in patients with mild Alzheimer's disease: a pilot phase 2 clinical trial 2008-10-30
Studies
4 studies carry this tag.
Date range
2006 to 2016
Top journals
- Annals of neurology 1
- Journal of neural transmission (Vienna, Austria : 1996) 1
- Neurology 1
- Scientific reports 1
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Quantitative Susceptibility Mapping (QSM) MRI at 7 Tesla and 11-Carbon Pittsburgh-Compound-B PET were used for investigating the relationship between brain iron and Amyloid beta (Aβ) plaque-load in a context of increased risk for Alzheimer's disease (AD), as reflected by the Apolipoprotein E ε4 (APOE-e4) allele and mild cognitive impairment (MCI) in elderly subjects.
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Among the evaluated parameters, the only significant predictor of conversion to AD was non-Cp copper (hazard ratio = 1.23, 95% confidence interval = 1.03-1.47, p = 0.022); for each additional micromole per liter unit (μmol/l) of non-Cp copper, the hazard increased by ~20%.
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A plethora of reports suggest that copper (Cu) homeostasis is disturbed in Alzheimer's disease (AD).
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Brain zinc accumulation is a prominent feature of advanced Alzheimer disease (AD) and is biochemically linked to brain amyloid beta-peptide accumulation and dementia severity in AD.