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Home › Research › Topics › mapt

mapt

3 studies tagged mapt, dated 2012-08-20 to 2019-06-28. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration 2019-06-28
  2. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus 2015-02-17
  3. Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort 2012-08-20

Studies

3 studies carry this tag.

Date range

2012 to 2019

Top journals

  • Alzheimer's research & therapy 1
  • Autophagy 1
  • Molecular psychiatry 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Autophagy 2019-06-28 Tau biomarkers

    Here, we found that overexpression of human wild-type full-length MAPT, which models MAPT pathologies as seen in sporadic AD patients, induced autophagy deficits via repression of autophagosome-lysosome fusion leading to significantly increased LC3 (microtubule-associated protein 1 light chain 3)-II and SQSTM1/p62 (sequestosome 1) protein levels with autophagosome accumulation.

  2. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Molecular psychiatry 2015-02-17 Genetics

    We investigated the genetic overlap between Alzheimer's disease (AD) and Parkinson's disease (PD).

  3. Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's research & therapy 2012-08-20 Genetics

    We found pathogenic mutations in PSEN1, GRN and MAPT in 2.33% of the screened cases.

All topic tags with their study counts