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Home › Research › Topics › loss-of-function

loss-of-function

2 studies tagged loss-of-function, dated 2020-07-01 to 2023-03-13. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model 2023-03-13
  2. Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models 2020-07-01

Studies

2 studies carry this tag.

Date range

2020 to 2023

Top journals

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1
  • iScience 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. iScience 2023-03-13 TREM2 and immune genetics

    The genetic associations of TREM2 loss-of-function variants with Alzheimer disease (AD) indicate the protective roles of microglia in AD pathogenesis.

  2. Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020-07-01 TREM2 and immune genetics

    Mutation of Triggering receptor expressed on myeloid cells 2 (TREM2) impairs the response of microglia to amyloid-β (Aβ) pathology in Alzheimer's disease (AD), although the mechanism governing TREM2-regulated microglia recruitment to Aβ plaques remains unresolved.

All topic tags with their study counts