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Home › Research › Topics › early-onset

early-onset

7 studies tagged early-onset, dated 2004-11-01 to 2020-09-14. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer's disease 2020-09-14
  2. Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model 2019-12-04
  3. Two novel presenilin-1 mutations (I249L and P433S) in early onset Chinese Alzheimer's pedigrees and their functional characterization 2019-06-21

Studies

7 studies carry this tag.

Date range

2004 to 2020

Top journals

  • Acta neuropathologica 1
  • Aging 1
  • Archives of neurology 1
  • Biochemical and biophysical research communications 1
  • European journal of neurology 1

7 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Acta neuropathologica 2020-09-14 Biomarkers

    Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) deposits, which come in myriad morphologies with varying clinical relevance.

  2. Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Aging 2019-12-04 Biomarkers

    The implication of epigenetic mechanisms in Alzheimer's disease (AD) has been demonstrated in several studies.

  3. Two novel presenilin-1 mutations (I249L and P433S) in early onset Chinese Alzheimer's pedigrees and their functional characterization

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biochemical and biophysical research communications 2019-06-21 Biomarkers

    Clinical case study and functional characterization of the disease-associated presenilin-1 (PSEN1) mutations may help reveal the roles of PSEN1 in the pathogenesis of Alzheimer's disease (AD).

  4. A Novel PSEN1 M139L Mutation Found in a Chinese Pedigree with Early-Onset Alzheimer's Disease Increases Aβ42/Aβ40 ratio

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD 2019-01-01 Biomarkers

    The novel PSEN1 M139L mutation found in familial AD increases the Aβ42/Aβ40 ratio significantly.

  5. Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience letters 2010-11-19 Biomarkers

    Familial Alzheimer's disease (AD) due to PSEN1 mutations provides an opportunity to examine AD biomarkers in persons in whom the diagnosis is certain.

  6. A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. European journal of neurology 2008-08-22 Biomarkers

    The possible pathogenic nature of the mutation is not clarified.

  7. A novel presenilin-1 mutation (Leu85Pro) in early-onset Alzheimer disease with spastic paraparesis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Archives of neurology 2004-11-01 Biomarkers

    The Leu85Pro mutation in PSEN1 was pathogenic.

All topic tags with their study counts