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Home › Research › Topics › dynamics

dynamics

4 studies tagged dynamics, dated 2016-02-04 to 2020-12-09. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer's disease and implicate its dynamic role in disease progression 2020-12-09
  2. The dynamics of biomarkers across the clinical spectrum of Alzheimer's disease 2020-06-13
  3. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production 2017-02-13

Studies

4 studies carry this tag.

Date range

2016 to 2020

Top journals

  • Alzheimer's research & therapy 1
  • Clinical epigenetics 1
  • Molecular neurodegeneration 1
  • Neurobiology of disease 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Longitudinal data in peripheral blood confirm that PM20D1 is a quantitative trait locus (QTL) for Alzheimer's disease and implicate its dynamic role in disease progression

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Clinical epigenetics 2020-12-09 Biomarkers

    Our results confirm that PM20D1 is an mQTL in AD and demonstrate that it plays a dynamic role at different stages of the disease.

  2. The dynamics of biomarkers across the clinical spectrum of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Alzheimer's research & therapy 2020-06-13 Biomarkers

    Despite the limited longitudinal data at the individual level and the high variability observed in such data, the study elucidates the link between the long asynchronous pathophysiological processes and the preclinical and clinical stages of AD.

  3. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2017-02-13 Biomarkers

    We demonstrate that targeted inhibition of the PS1-Syt1 binding in neurons, without changing the proteins' expression level, triggers "pathogenic" conformational shift of PS1, and consequent increase in the Aβ42/40 ratio.

  4. The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of disease 2016-02-04 Biomarkers

    There is no molecular explanation for the many presenilin 1 (PSEN1) mutations causing Alzheimer's disease, but both gain of function relating to amyloid production and loss of isolated PSEN1 function have been implied.

All topic tags with their study counts