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cd33
4 studies tagged cd33, dated 2011-07-28 to 2021-02-04. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype 2021-02-04
- Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia 2020-02-01
- Evaluation of CD33 as a genetic risk factor for Alzheimer's disease 2019-04-04
Studies
4 studies carry this tag.
Date range
2011 to 2021
Top journals
- Acta neuropathologica 1
- Food & function 1
- Glia 1
- Molecular neurodegeneration 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Genome-wide association studies demonstrated that polymorphisms in the CD33/sialic acid-binding immunoglobulin-like lectin 3 gene are associated with late-onset Alzheimer's disease (AD).
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Alzheimer's disease, characterized by neuroinflammation and beta-amyloid protein plaques, is a memory-threatening neurodegenerative disease with no effective treatment.
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In 2011, genome-wide association studies implicated a polymorphism near CD33 as a genetic risk factor for Alzheimer's disease.
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Our data overwhelmingly support the association of EPHA1 and CD33 variants with LOAD risk: addition of our data to the results previously reported (total n > 42,000) increased the strength of evidence for these variants, providing impressive p-values of 2.1 × 10-15 (EPHA1) and 1.8 × 10-13 (CD33).