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Home › Research › Topics › autophagy

autophagy

241 studies tagged autophagy, dated 1993-05-01 to 2026-10-30. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Disrupting SORL1-retromer endosomal recycling in mice drives the age-dependent neurodegenerative signature of Alzheimer's disease 2026-10-30
  2. TMEM106B C-Terminal fragment aggregation exacerbates α-synuclein and TDP-43 proteinopathy phenotypes 2026-10-30
  3. The Filamin A Proteomic Switch: Solubility States and Cytoskeletal Dynamics Explain the Inverse Epidemiological Relationship Between Cancer and Alzheimer’s Disease 2026-10-26

Studies

241 studies carry this tag.

Date range

1993 to 2026

Top journals

  • Autophagy 9
  • bioRxiv 9
  • Nature 8
  • Nature communications 6
  • Acta neuropathologica 5

145 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2023-11-27 Drug development

    The spectrum of neurodegenerative diseases known today is quite extensive.

  2. The Unfolded Protein Response in a Murine Model of Alzheimer's Disease: Looking for Predictors

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2023-11-11 Disease mechanisms

    Alzheimer's disease (AD) represents the most frequent type of dementia worldwide, and aging is the most important risk factor for the sporadic form of the pathology.

  3. Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2023-11-02 Disease mechanisms

    Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta and tau proteins.

  4. Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta pharmaceutica Sinica. B 2023-10-21 Disease mechanisms

    Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer's disease (AD) collectively culminate in neuronal deterioration.

  5. Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. GeroScience 2023-09-25 Disease mechanisms

    We have recently shown that multiple tRNA synthetase inhibitors can greatly increase lifespan in multiple models by acting through the conserved transcription factor ATF4.

  6. Biochemical and Molecular Pathways in Neurodegenerative Diseases: An Integrated View

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2023-09-20 Disease mechanisms

    Neurodegenerative diseases (NDDs) like Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) are defined by a myriad of complex aetiologies.

  7. α-Synuclein pathology in post-mortem retina and optic nerve is specific for α-synucleinopathies

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. NPJ Parkinson's disease 2023-08-28 Brain tissue and pathology

    There is increasing interest in studying retinal biomarkers for various neurodegenerative diseases.

  8. HtrA1 prevents and reverses α-synuclein aggregation, rendering it non-toxic and seeding incompetent

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2023-08-22 Brain tissue and pathology

    Parkinson disease (PD) is closely linked to the misfolding and accumulation of α-synuclein (α-syn) into Lewy bodies.

  9. A Systematic Compilation of Human SH3 Domains: A Versatile Superfamily in Cellular Signaling

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2023-08-12 Prevention trials

    SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of protein complexes through physical interactions with a pool of proline-rich/noncanonical motifs from partner proteins.

  10. Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2023-05-29 Genetics

    Retromer controls cellular homeostasis through regulating integral membrane protein sorting and transport and by controlling maturation of the endo-lysosomal network.

  11. CSF alpha-synuclein aggregates by seed amplification and clinical presentation of AD

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2023-04-27 Brain tissue and pathology

    CSF was αSyn-SAA positive (αSyn+) in 36/80 AD patients (45%) and in 2/28 controls (7.1%).

  12. Aggregation of Disordered Proteins Associated with Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2023-02-08 Brain tissue and pathology

    Cellular deposition of protein aggregates, one of the hallmarks of neurodegeneration, disrupts cellular functions and leads to neuronal death.

  13. Defective proteostasis in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Ageing research reviews 2023-01-21 Disease mechanisms

    The homeostasis of cellular proteins, or proteostasis, is critical for neuronal function and for brain processes, including learning and memory.

  14. Frontotemporal Dementia Patient Neurons With Progranulin Deficiency Display Protein Dyshomeostasis

    ⚠ Preprint — not yet peer-reviewed alzhub usefulness score 16 out of 100. bioRxiv : the preprint server for biology 2023-01-20 Disease mechanisms

    Haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), a devastating neurodegenerative disease with no effective treatment.

  15. TTR (transthyretin) leads the autophagy disaster relief team against TARDBP/TDP-43 proteinopathy

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Autophagy 2023-01-18 Disease mechanisms

    TTR (transthyretin) strikes a neuroprotective function in the prevention of amyloid-β (Aβ) deposition in Alzheimer disease (AD).

  16. Aluminum neurotoxicity and autophagy: a mechanistic view

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurological research 2022-10-08 Disease mechanisms

    It is strongly believed that aluminum is one of the insalubrious agents because of its neurotoxicity effects and influences on amyloid β (Aβ) production and tau protein hyperphosphorylation following oxidative stress, as one of the initial events in neurotoxicity.

  17. Interaction between autophagy and the NLRP3 inflammasome in Alzheimer's and Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2022-10-03 Inflammation and the immune system

    Autophagy degrades phagocytosed damaged organelles, misfolded proteins, and various pathogens through lysosomes as an essential way to maintain cellular homeostasis.

  18. Distinct neurotoxic TDP-43 fibril polymorphs are generated by heterotypic interactions with α-Synuclein

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Journal of biological chemistry 2022-09-16 Brain tissue and pathology

    Amyloid aggregates of specific proteins constitute important pathological hallmarks in many neurodegenerative diseases, defining neuronal degeneration and disease onset.

  19. Supramolecular organizing centers at the interface of inflammation and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in immunology 2022-08-01 Inflammation and the immune system

    The pathogenesis of neurodegenerative diseases involves the accumulation of misfolded protein aggregates.

  20. Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Nature neuroscience 2022-06-02 Risk genes beyond APOE

    Autophagy is markedly impaired in Alzheimer's disease (AD).

  21. Favorably against the odds - autophagy control despite advanced amyloid- ß toxicity

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Autophagy reports 2022-05-30 Disease mechanisms

    Alzheimer disease (AD) is a devastating condition associated with loss of proteostasis control and autophagy failure, leading to progressive neuronal cell death.

  22. PSEN1 G417S mutation in a Chinese pedigree causing early-onset parkinsonism with cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 2022-04-11 Risk genes beyond APOE

    Presenilin 1 (PSEN1) mutations are a major cause of familial Alzheimer's disease.

  23. Repurposing small-molecule drugs for modulating toxic protein aggregates in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Drug discovery today 2022-04-06 Drug development

    Neurodegenerative diseases (NDs) are often age-related disorders that can cause dementia in people, usually over 65 years old, are still lacking effective therapies.

  24. α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biomolecules 2022-03-27 Brain tissue and pathology

    α-synuclein (α-syn) is a presynaptic, lipid-binding protein strongly associated with the neuropathology observed in Parkinson's disease (PD), dementia with Lewy bodies (DLB), and Alzheimer's Disease (AD).

  25. Enhancing autophagy in Alzheimer's disease through drug repositioning

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Pharmacology & therapeutics 2022-03-16 Drug development

    Alzheimer's disease (AD) is one of the biggest human health threats due to increases in aging of the global population.

  26. Structural Basis for Chaperone-Independent Ubiquitination of Tau Protein by Its E3 Ligase CHIP

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Angewandte Chemie (International ed. in English) 2022-02-18 Prevention trials

    The multi-site ubiquitination of Tau protein found in Alzheimer's disease filaments hints at the failed attempt of neurons to remove early toxic species.

  27. TRPMLs and TPCs: Targets for lysosomal storage and neurodegenerative disease therapy?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell calcium 2022-02-05 Disease mechanisms

    Neurodegenerative diseases (ND) pose a serious health burden to society and healthcare systems alike, with increasing incidence rates especially within aging populations.

  28. Protein degradation-associated mechanisms that are affected in Alzheimer´s disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular and cellular biochemistry 2022-01-27 Disease mechanisms

    Alzheimer's disease (AD) is the most common type of dementia associated with age-related neurodegeneration.

  29. PROTACs technology for treatment of Alzheimer's disease: Advances and perspectives

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Acta materia medica 2022-01-21 Disease mechanisms

    Neurodegenerative diseases (NDs) are characteristic with progression of neuron degeneration, resulting in dysfunction of cognition and mobility.

  30. TREM2 Gene Compound Heterozygosity in Neurodegenerative Disorders

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of Alzheimer's disease : JAD 2022 TREM2 and immune genetics

    We identified a novel mutation c.401_406delinsTCTAT; p.(Asp134Valfs*55) in exon 3 of TREM2 in an Alzheimer's disease patient also carrying the p.Arg62His TREM2 variant.

  31. Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature medicine 2021-12-23 Drug development

    Expansions of a G 4 C 2 repeat in the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two devastating adult-onset neurodegenerative disorders.

  32. α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell & bioscience 2021-11-19 Brain tissue and pathology

    Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain.

  33. Protein clearance strategies for disease intervention

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neural transmission (Vienna, Austria : 1996) 2021-10-23 Disease mechanisms

    Protein homeostasis, or proteostasis, is essential for cell function and viability.

  34. Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurodegeneration 2021-09-09 Brain tissue and pathology

    Immunohistochemical analysis of M20/L85 mice revealed that pre-existing Aβ plaques exacerbate the spread and deposition of induced α-synuclein pathology.

  35. Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Ageing research reviews 2021-07-31 Disease mechanisms

    One evident hallmark of Alzheimer's disease (AD) is the irregular accumulation of proteins due to changes in proteostasis involving endoplasmic reticulum (ER) stress.

  36. Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Protein & cell 2021-07-21 Drug development

    Chaperone-mediated autophagy (CMA) is a lysosome-dependent selective degradation pathway implicated in the pathogenesis of cancer and neurodegenerative diseases.

  37. Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Free radical biology & medicine 2021-07-02 Disease mechanisms

    Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease are characterized by progressive degeneration of synapses and neurons.

  38. Chemical-Mediated Targeted Protein Degradation in Neurodegenerative Diseases

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Life (Basel, Switzerland) 2021-06-24 Disease mechanisms

    Neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, and Parkinson's disease, are a class of diseases that lead to dysfunction of cognition and mobility.

  39. Chaperone-mediated autophagy: a gatekeeper of neuronal proteostasis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Autophagy 2021-06-10 Disease mechanisms

    Different types of autophagy co-exist in all mammalian cells, however, the specific contribution of each of these autophagic pathways to the maintenance of cellular proteostasis and cellular function remains unknown.

  40. Molecular mechanisms of cell death in neurological diseases

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cell death and differentiation 2021-06-07 Disease mechanisms

    Tightly orchestrated programmed cell death (PCD) signalling events occur during normal neuronal development in a spatially and temporally restricted manner to establish the neural architecture and shaping the CNS.

  41. SORL1 deficiency in human excitatory neurons causes APP-dependent defects in the endolysosome-autophagy network

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Cell reports 2021-06-01 Drug development

    Dysfunction of the endolysosomal-autophagy network is emerging as an important pathogenic process in Alzheimer's disease.

  42. Autophagy and ALS: mechanistic insights and therapeutic implications

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Autophagy 2021-05-31 Disease mechanisms

    Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons and other cells of the central nervous system.

  43. Proteolytic α-Synuclein Cleavage in Health and Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences 2021-05-21 Brain tissue and pathology

    In Parkinson's disease, aggregates of α-synuclein within Lewy bodies and Lewy neurites represent neuropathological hallmarks.

  44. Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Translational neurodegeneration 2021-05-20 Drug development

    Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene expression that systematically removes non-coding regions (introns) and ligates coding regions (exons) into a continuous message (mature mRNA).

  45. Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Antioxidants (Basel, Switzerland) 2021-04-28 Disease mechanisms

    Autophagy, a main degradation pathway for maintaining cellular homeostasis, and redox homeostasis have recently been considered to play protective roles in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis.

  46. Dementia with Lewy bodies: emerging drug targets and therapeutics

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Expert opinion on investigational drugs 2021-04-26 Drug development

    Dementia with Lewy bodies (DLB) is characterized by the toxic accumulation of α-synuclein protein inside neural cells; this results in neurodegeneration which is clinically accompanied by behavioral and psychological changes.

  47. Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell 2021-04-22 Disease mechanisms

    Components of the proteostasis network malfunction in aging, and reduced protein quality control in neurons has been proposed to promote neurodegeneration.

  48. C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Autophagy 2021-02-26 Drug development

    Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two clinically distinct classes of neurodegenerative disorders.

  49. Nuclear Ubiquitin-Proteasome Pathways in Proteostasis Maintenance

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Biomolecules 2021-01-04 Disease mechanisms

    Protein homeostasis, or proteostasis, is crucial for the functioning of a cell, as proteins that are mislocalized, present in excessive amounts, or aberrant due to misfolding or other type of damage can be harmful.

  50. Current Clinical Applications of In Vivo Gene Therapy with AAVs

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular therapy : the journal of the American Society of Gene Therapy 2020-12-10 Brain scans and imaging

    Hereditary diseases are caused by mutations in genes, and more than 7,000 rare diseases affect over 30 million Americans.

From across this tag

9 of the 241 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts