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als
4 studies tagged als, dated 2018-09-17 to 2023-04-03. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Elevated plasma p-tau181 levels unrelated to Alzheimer's disease pathology in amyotrophic lateral sclerosis 2023-04-03
- Elevated Plasma Phosphorylated Tau 181 in Amyotrophic Lateral Sclerosis 2022-08-17
- The diagnostic performance of neurofilament light chain in CSF and blood for Alzheimer's disease, frontotemporal dementia, and amyotrophic lateral sclerosis: A systematic review and meta-analysis 2019-11-04
Studies
4 studies carry this tag.
Date range
2018 to 2023
Top journals
- Journal of neurology, neurosurgery, and psychiatry 2
- Alzheimer's & dementia (Amsterdam, Netherlands) 1
- Annals of neurology 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Plasma p-tau181 is elevated in patients with ALS, independently from CSF levels, and is firmly associated with LMN dysfunction.
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We found strong evidence that plasma p-tau 181 is elevated in ALS and may be a novel marker specific to LMN dysfunction.
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Comparable performance of CSF and blood NfL in many groups demonstrates the promise of NfL as a noninvasive biomarker of neurodegeneration; however, its utility in clinically meaningful scenarios requires greater scrutiny.
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Our data indicate that neuroinflammation is linked to the symptomatic phase of ALS/FTD and shows a similar pattern in sporadic and genetic cases.