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Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain
Yasojima K, McGeer EG, McGeer PL.. Brain research, 2001-11-01
Topic: Amyloid, tau and blood-test diagnosis
beta-Amyloid peptide (Abeta) is generated by two cleavages of amyloid precursor protein (APP). The initial cleavage by BACE is followed by gamma-secretase cleavage of the C-terminal APP fragment. Presenilin-1 (PS-1) is intimately related to gamma-secretase.
Key findings
- The initial cleavage by BACE is followed by gamma-secretase cleavage of the C-terminal APP fragment.
- Presenilin-1 (PS-1) is intimately related to gamma-secretase.
- Once formed, Abeta is mainly broken down by neprilysin.
- To estimate vulnerability to Abeta senile plaque formation, we measured the relative mRNA levels of APP695, APP751, APP770, BACE, presenilin-1 (PS-1) and neprilysin in nine brain areas and in heart, liver, spleen and kidney in a series of Alzheimer disease (AD) and control cases.
Why it matters
This study measured mRNA levels of amyloid precursor protein forms, BACE, presenilin-1, and neprilysin across nine brain areas and several organs in Alzheimer's disease and control cases to estimate vulnerability to amyloid plaque formation. It is a descriptive comparison of gene expression and does not test any treatment, cure, or prevention.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Brain research) |
| Journal's citation record | 3 / 4 | Brain Research: journal h-index 399 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2001 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 226 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 8.4 citations a year over 27 year(s) since 2001 |
| Impact for its field and year | 3 / 6 | Cited 5.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 7 other studies in this library |
| Still being cited | 1 / 4 | Cited 14 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Patrick L. McGeer: h-index 119 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of British Columbia: institution h-index 1,424 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 11689168) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Yasojima, K., McGeer, E. G., & McGeer, P. L. (2001). Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain. Brain research. https://doi.org/10.1016/s0006-8993(01)03008-6
Vancouver
Yasojima K, McGeer EG, McGeer PL. Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain. Brain research. 2001. doi:10.1016/s0006-8993(01)03008-6. PMID: 11689168.
BibTeX
@article{yasojima2001-11689168,
author = {Yasojima, K. and McGeer, E. G. and McGeer, P. L.},
title = {{Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain}},
journal = {Brain research},
year = {2001},
doi = {10.1016/s0006-8993(01)03008-6},
pmid = {11689168},
url = {https://doi.org/10.1016/s0006-8993(01)03008-6}
}
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