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Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, Sudwarts A, Recupero AJ et al.. Cell reports, 2020-03-01
Topic: Brain proteins, microglia and lab models
BIN1, a member of the BAR adaptor protein family, is a significant late-onset Alzheimer disease risk factor. Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models. Loss of neuronal Bin1 expression results in the select impairment of spatial learning and memory.
Key findings
- Here, we investigate BIN1 function in the brain using conditional knockout (cKO) models.
- Loss of neuronal Bin1 expression results in the select impairment of spatial learning and memory.
- Examination of hippocampal CA1 excitatory synapses reveals a deficit in presynaptic release probability and slower depletion of neurotransmitters during repetitive stimulation, suggesting altered vesicle dynamics in Bin1 cKO mice.
- Super-resolution and immunoelectron microscopy localizes BIN1 to presynaptic sites in excitatory synapses.
Why it matters
In mice, loss of neuronal BIN1 caused impairment in spatial learning and memory and changes in presynaptic neurotransmitter release. This is an animal study and does not show any treatment, cure, or prevention for Alzheimer's disease in humans.
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Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cell reports) |
| Journal's citation record | 3 / 4 | Cell Reports: journal h-index 321 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 117 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.6 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 3 / 6 | Cited 6.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 54 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Gopal Thinakaran: h-index 67 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University of Chicago: institution h-index 1,769 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32160554) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
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Read the original
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Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
De Rossi, P., Nomura, T., Andrew, R. J., Masse, N. Y., Sampathkumar, V., Musial, T. F., et al. (2020). Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. Cell reports. https://doi.org/10.1016/j.celrep.2020.02.026
Vancouver
De Rossi P, Nomura T, Andrew RJ, Masse NY, Sampathkumar V, Musial TF, et al. Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. Cell reports. 2020. doi:10.1016/j.celrep.2020.02.026. PMID: 32160554.
BibTeX
@article{derossi2020-32160554,
author = {De Rossi, P. and Nomura, T. and Andrew, R. J. and Masse, N. Y. and Sampathkumar, V. and Musial, T. F. and Sudwarts, A. and Recupero, A. J. and others},
title = {{Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation}},
journal = {Cell reports},
year = {2020},
doi = {10.1016/j.celrep.2020.02.026},
pmid = {32160554},
url = {https://doi.org/10.1016/j.celrep.2020.02.026}
}
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