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283 results for "driving".

Research summaries 260

Showing the best 200 of 260, 61–70, page 7 of 20. Filter these by subject, year and score in the research library →

1. Patient‐derived forebrain cortical organoids reveal biphasic tau–MAP6–microtubule axis dysfunction in tauopathyResearch summary

   Research summaries · alzhub.org/study/patientderived-forebrain-cortical-organoids-reveal-biphasic-42411568

   … tau-MAP6-microtubule mechanism driving tauopathy and establishes these organoids as a platform for phase-specific therapy. In patient-derived brain organoids, early-phase tau mutant tissue showed elevated tau and hyperdynamic …

2. Reduced phosphatases and hyperphosphorylated glutamatergic receptors persist from early to late stages of prion diseaseResearch summary

   Research summaries · alzhub.org/study/reduced-phosphatases-and-hyperphosphorylated-glutamatergic-receptors-c51e2b7b

   … intracellular signaling driving this dysregulation remains poorly understood. Evidence of neuronal hyperactivity was reported in humans with sporadic and familial CJD as well as in the early stages of prion disease in mice …

3. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathologyResearch summary

   Research summaries · alzhub.org/study/sustained-hippocampal-il-1-beta-overexpression-mediates-chronic-17549256

   … that was capable of driving robust neuroinflammation lasting months after transgene activation. In a transgenic mouse model, sustained overexpression of IL-1 beta caused chronic neuroinflammation but surprisingly reduced …

4. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to TherapeuticsResearch summary

   Research summaries · alzhub.org/study/the-amyloid-hypothesis-of-alzheimer-s-disease-progress-and-problems-12130773

   … the primary influence driving AD pathogenesis. The rest of the disease process, including formation of neurofibrillary tangles containing tau protein, is proposed to result from an imbalance between Abeta production and Abeta …

5. Aggressive, socially disruptive and antisocial behaviour associated with fronto-temporal dementiaResearch summary

   Research summaries · alzhub.org/study/aggressive-socially-disruptive-and-antisocial-behaviour-associated-9093504

   … shoplifting and hit-and-run driving. Three FTD subjects were arrested. This difference was highly significant (P = 0.004). Conclusions Degeneration of frontal and temporal lobes predisposes to antisocial behaviour. This study …

6. Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/alpha-synuclein-co-pathology-is-associated-with-accelerated-amyloid-40098057

   … tau pathology thereby driving faster cognitive decline. This highlights that a-Syn co-pathology may specifically accelerate amyloid-driven tau pathophysiology in AD, underscoring the need to consider αSyn in AD research and …

7. Assessment and diagnosis of dementia in Hispanic and non-Hispanic white outpatientsResearch summary

   Research summaries · alzhub.org/study/assessment-and-diagnosis-of-dementia-in-hispanic-and-non-hispanic-23348889

   … questionable and they may be driving systematic differences in diagnosis within and across ethnicities. In addition, informant-reported functional abilities may be less sensitive to ethnicity-related influences and represent an …

8. Associations of Longitudinal Changes in Blood Biomarkers of Dementia With the Proportion of Genetically Inferred African AncestryResearch summary

   Research summaries · alzhub.org/study/associations-of-longitudinal-changes-in-blood-biomarkers-of-dementia-40779734

   … across ancestry and the driving biological or sociocultural factors. In this African American cohort, a higher proportion of genetically inferred African ancestry was suggestively linked to a slower rise in blood p-Tau181 over …

9. BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathologyResearch summary

   Research summaries · alzhub.org/study/bad-mediated-neuronal-apoptosis-and-neuroinflammation-contribute-to-34430820

   … to AD pathologies by driving neuronal apoptosis and neuroinflammation but suppressing microglial phagocytosis of Aβ, suggesting that BAD is a potential therapeutic target for AD. BAD pro-apoptotic activity is significantly …

10. Be a Super Shopper!Research summary

    Research summaries · alzhub.org/study/be-a-super-shopper-ff072978

    … as powerful mechanism driving precautionary consumption. While Whole Foods Market is not the only market actor encouraging precautionary consumption, the company has helped to mark the grocery store as a site where a new, much …

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