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292 results for "driving".

Research summaries 269

Showing the best 200 of 269, 191–200, page 20 of 20. Filter these by subject, year and score in the research library →

1. Making the final cut: pathogenic amyloid-β peptide generation by γ-secretaseResearch summary

   Research summaries · alzhub.org/study/making-the-final-cut-pathogenic-amyloid-peptide-generation-by-31225454

   … side also been a major driving force for structural and in depth mechanistic studies on this key AD drug target in the past few years. Cell stress 2018 genetics_genes Steiner H, Fukumori A, Tagami S, Okochi M.

2. Metabolic Syndrome and the Cellular Phase of Alzheimer's DiseaseResearch summary

   Research summaries · alzhub.org/study/metabolic-syndrome-and-the-cellular-phase-of-alzheimer-s-disease-28253987

   … play critical roles in driving neuroinflammation, an important cause of AD pathogenesis. Studies of MetS and AD have traditionally remained in distinct domains. The cross talk between MetS and the cellular phase of AD is an …

3. Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse modelResearch summary

   Research summaries · alzhub.org/study/microglia-drive-apoe-dependent-neurodegeneration-in-a-tauopathy-mouse-31601677

   … is the leading force driving neurodegeneration in a tauopathy mouse model. Importantly, the progression of ptau pathology is also driven by microglia. In addition, we found that APOE, the strongest genetic risk factor for AD, …

4. Near infrared light decreases synaptic vulnerability to amyloid beta oligomersResearch summary

   Research summaries · alzhub.org/study/near-infrared-light-decreases-synaptic-vulnerability-to-amyloid-beta-29118388

   … Alzheimer's Disease (AD), driving initial cognitive deficits and clinical manifestation. Consequently, there is ample consensus that preventing early synaptic dysfunction would be an effective therapeutic strategy for AD. With …

5. Neuroinflammation in Alzheimer diseaseResearch summary

   Research summaries · alzhub.org/study/neuroinflammation-in-alzheimer-disease-39653749

   … their interactions are driving forces behind the spread and progression of the disease. The identification of treatment opportunities will require a precise understanding of the cells and mechanisms involved as well as a clear …

6. New Insights into the Spontaneous Human Alzheimer's Disease-Like Model Octodon degus: Unraveling Amyloid-β Peptide Aggregation and Age-Related Amyloid PathologyResearch summary

   Research summaries · alzhub.org/study/new-insights-into-the-spontaneous-human-alzheimer-s-disease-like-30412496

   … the molecular milieu driving AD pathophysiology, no effective therapy is currently available. Moreover, various clinical trials have continued to fail, suggesting that our approach to AD must be revised. Accordingly, the …

7. New pharmacologic agents for insomnia and hypersomniaResearch summary

   Research summaries · alzhub.org/study/new-pharmacologic-agents-for-insomnia-and-hypersomnia-32890017

   … and possible next-day driving impairment, should be discussed for all agents used for insomnia, including orexin receptor antagonists. Novel agents also are available for hypersomnia and there are options beyond traditional …

8. PCSK9 and High-Fat Diet Synergistically Induce Neurovascular Dysfunction and NeuroinflammationResearch summary

   Research summaries · alzhub.org/study/pcsk9-and-high-fat-diet-synergistically-induce-neurovascular-41278621

   … environmental risk factors driving cerebrovascular pathology in metabolic syndrome are poorly understood. Here, we characterize neuroinflammatory and neurodegenerative phenotypes in a mouse model of metabolic syndrome with …

9. PIN1-p53 bifurcation dictates opposite cell fate decisions in Alzheimer’s disease and glioblastoma via distinct energy landscape topologiesResearch summary

   Research summaries · alzhub.org/study/pin1-p53-bifurcation-dictates-opposite-cell-fate-decisions-in-d9d173bc

   … system-level mechanisms driving this striking divergence remain elusive. Here, we integrated single-cell and single-nucleus transcriptomic data from AD (84 donors) and GBM (18 samples) to comparatively map the energy landscape of …

10. Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's diseaseResearch summary

    Research summaries · alzhub.org/study/peripheral-innate-immune-and-bacterial-signals-relate-to-clinical-32006615

    … of the components and driving mechanisms involved and their relationship with clinical heterogeneity and progression to dementia remain poorly explored. We examined changes in peripheral innate immune-related markers in PD cases …

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