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287 results for "driving".

Research summaries 264

Showing the best 200 of 264, 111–120, page 12 of 20. Filter these by subject, year and score in the research library →

1. In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome RecruitmentResearch summary

   Research summaries · alzhub.org/study/in-situ-structure-of-neuronal-c9orf72-poly-ga-aggregates-reveals-29398115

   … neuronal proteostasis by driving the accumulation and functional impairment of a large fraction of cellular proteasomes. Using cryo-electron tomography in intact neurons, this study found that poly-GA aggregates from the C9orf72 …

2. In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's diseaseResearch summary

   Research summaries · alzhub.org/study/in-vivo-imaging-of-microglial-activation-with-11c-r-pk11195-pet-in-16182554

   … relatively static, possibly driving the disease via cytokine release. In 18 Parkinson's disease patients, PET imaging showed increased microglial activation in several brain regions compared with 11 controls, and this signal …

3. Integrative Multiomics Analysis Reveals a Coordinated Molecular Signature of Neuroresilience in human MAPT-knockout hiPSC-derived Neurons with relevance for Alzheimer’s and Neurodegenerative DiseaseResearch summary

   Research summaries · alzhub.org/study/integrative-multiomics-analysis-reveals-a-coordinated-molecular-f5a97635

   … molecular reprogramming driving this neuroresilience remains poorly defined. Methods We employed an integrative multiomics approach, combining temporal transcriptomics (3h and 24h post-Aβ exposure) with newly processed proteomic …

4. Magnetic Field–Enhanced Docosahexaenoic Acid Delivery for Acetylcholine Restoration in Alzheimer’s Disease: an In Silico StudyResearch summary

   Research summaries · alzhub.org/study/magnetic-fieldenhanced-docosahexaenoic-acid-delivery-for-cfdd9ac7

   … relative to baseline, driving ACh to 133.7% of threshold versus only 18.1% without the field. A Brain Computer Interface (BCI)-based closed-loop dosing framework is additionally proposed for future clinical validation. These …

5. Neuroimaging Compendium of Microglia, Amyloid, Tau, and Neurodegeneration Across Clinical Variants of Alzheimer DiseaseResearch summary

   Research summaries · alzhub.org/study/neuroimaging-compendium-of-microglia-amyloid-tau-and-41288284

   … patterns of amyloid and tau driving symptomatology, but the distribution of microglia density, as measured by 18kDa translocator protein (TSPO) PET, is unknown. Baseline TSPO, amyloid, and tau PET as well as T1 MRI from the …

6. Neuroimaging and plasma biomarker differences and commonalities in Lewy body dementia subtypesResearch summary

   Research summaries · alzhub.org/study/neuroimaging-and-plasma-biomarker-differences-and-commonalities-in-40403153

   … distinct from those driving dementia. The presence of dementia in Lewy body disease was associated with poorer white matter macrostructure and may relate to pathological protein accumulation, with plasma neurofilament light and …

7. Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleepResearch summary

   Research summaries · alzhub.org/study/norepinephrine-mediated-slow-vasomotion-drives-glymphatic-clearance-39788123

   … vasomotion acts as a pump driving CSF into the brain. On the contrary, the sleep aid zolpidem suppressed norepinephrine oscillations and glymphatic flow, highlighting the critical role of norepinephrine-driven vascular dynamics …

8. Obstructive sleep apnea, cognition and Alzheimer's disease: A systematic review integrating three decades of multidisciplinary researchResearch summary

   Research summaries · alzhub.org/study/obstructive-sleep-apnea-cognition-and-alzheimer-s-disease-a-31881487

   … sleep/cognitive-impairment driving these findings. CPAP treatment may be effective in improving cognition in OSA patients with AD. Recent trends demonstrate links between OSA and AD-biomarkers of neurodegeneration across all …

9. Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effectsResearch summary

   Research summaries · alzhub.org/study/oral-glp-1-receptor-agonist-promotes-astrocyte-neuron-lactate-and-42330959

   … aerobic glycolysis and driving lactate release. Astrocyte-derived lactate is taken up by neurons and elevates histone H3 lysine 9 lactylation (H3K9la), which in turn facilitates lipid transport from neurons back to astrocytes. …

10. Post-diagnostic support in Australia: Perspectives of people recently diagnosed with dementia and their carersResearch summary

    Research summaries · alzhub.org/study/post-diagnostic-support-in-australia-perspectives-of-people-recently-40223560

    … support; Support with driving concerns; Engaging and tailored information. Perspectives of people recently diagnosed with dementia and their carers identified the need to ensure that post-diagnostic support addressed their …

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