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439 results for "lecanemab".
Research summaries 393
Showing the best 200 of 393, 51–60, page 6 of 20. Filter these by subject, year and score in the research library →
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Real-world lecanemab adoption in Japan 1 year after launch: Insights from 311 specialists on infrastructure and reimbursement barriersResearch summary
Research summaries · alzhub.org/study/real-world-lecanemab-adoption-in-japan-1-year-after-launch-insights-41114448
Lecanemab was approved for early Alzheimer's disease in Japan, with ≈ 6000 patients treated in the first year post approval. This study explores real-world practices, challenges, and potential solutions. We conducted an …
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Research summaries · alzhub.org/study/mechanism-of-action-and-clinical-trial-results-of-lecanemab-leqembi-38692883
Lecanemab is a humanized monoclonal antibody directed against human soluble amyloid-β aggregates. It was developed for the treatment of early Alzheimer's disease (mild cognitive impairment or mild dementia stage of Alzheimer's …
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A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for lecanemabResearch summary
Research summaries · alzhub.org/study/a-real-world-disproportionality-analysis-of-fda-adverse-event-40242445
… (AEs) associated with lecanemab have been limited. Results A total of 811 AEs reports related to lecanemab used in AD patients and 506 AEs in Non-AD patients were included. Among these, ARIA-E, ARIA-H, brain oedema and status …
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Characterization of the Anti-Alzheimer Drug Lecanemab by Mass SpectrometryResearch summary
Research summaries · alzhub.org/study/characterization-of-the-anti-alzheimer-drug-lecanemab-by-mass-42368154
-glycans found at the N304 site of lecanemab of the heavy chain. Further analysis by MSFragger identified other modifications and additional glycosites. These results provide data as resource for the identification of critical …
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Disparities in Early Lecanemab Uptake Among US Medicare BeneficiariesResearch summary
Research summaries · alzhub.org/study/disparities-in-early-lecanemab-uptake-among-us-medicare-beneficiaries-40372759
… impairment received lecanemab and whether some groups were less likely to get it. It reports on uptake patterns only, not on whether the drug helped those patients. This cross-sectional study examines lecanemeb update among …
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Monoclonal Antibody Treatments for Alzheimer's Disease: Aducanumab and LecanemabResearch summary
Research summaries · alzhub.org/study/monoclonal-antibody-treatments-for-alzheimer-s-disease-aducanumab-and-39726673
… gantenerumab, solanezumab, and lecanemab. These treatment approaches are grounded in the hypothesis that a systemic failure in clearing Aβ contributes to the initiation and progression of AD. Recently, aducanumab and lecanemab …
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Review of Donanemab and Lecanemab in Mild Dementia Stage of Alzheimer's Disease: Progress and ChallengesResearch summary
Research summaries · alzhub.org/study/review-of-donanemab-and-lecanemab-in-mild-dementia-stage-of-alzheimer-41966037
… antibodies (mAbs), notably lecanemab and donanemab, which target Aβ pathology in early-stage AD. This review explores the clinical efficacy, safety profile, and limitations of lecanemab and donanemab, emphasizing key findings …
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Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer DiseaseResearch summary
Research summaries · alzhub.org/study/changes-of-a-cerebral-cavernous-malformation-associated-with-40584633
… treatment with intravenous lecanemab. Baseline MRI revealed 3 lobar microhemorrhages and an asymptomatic left orbitofrontal cavernous malformation. This cavernous malformation exhibited gross radiologic stability at surveillance …
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Clinical Practice Outcomes With Lecanemab for Alzheimer DiseaseResearch summary
Research summaries · alzhub.org/study/clinical-practice-outcomes-with-lecanemab-for-alzheimer-disease-42746606
… findings inform real-world lecanemab safety and efficacy. Dual ARIA-E peaks at ~10 and ~25 weeks underscore the need for ongoing MRI monitoring. Although several markers showed modest negative predictive value, none reliably …
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Lecanemab for mild Alzheimer disease - is there a way forward?Research summary
Research summaries · alzhub.org/study/lecanemab-for-mild-alzheimer-disease-is-there-a-way-forward-40078953
… and adverse effects of lecanemab amongst individuals with mild Alzheimer disease. Additionally, the recent controversy regarding the rejection by the EMA of a marketing authorization request for lecanemab, followed by its …
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