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17 results for "nitrate".

Research summaries 16

Showing 11–16, page 2 of 2. Filter these by subject, year and score in the research library →

1. Long-term effects of PM2.5 components on incident dementia in the northeastern United StatesResearch summary

   Research summaries · alzhub.org/study/long-term-effects-of-pm2-5-components-on-incident-dementia-in-the-35199078

   … 1.10) for inorganic nitrate, 1.03 (95% CI: 1.02, 1.04) for organic matter, 1.13 (95% CI: 1.11, 1.15) for sulfate, 1.07 (95% CI: 1.06, 1.07) for soil particles, and 1.04 (95% CI: 1.03, 1.05) for sea salt. Increase in exposure to …

2. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesionsResearch summary

   Research summaries · alzhub.org/study/oxidative-damage-linked-to-neurodegeneration-by-selective-alpha-11062131

   … antibodies to specific nitrated tyrosine residues in alpha-synuclein, we demonstrate extensive and widespread accumulations of nitrated alpha-synuclein in the signature inclusions of Parkinson's disease, dementia with Lewy …

3. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell deathResearch summary

   Research summaries · alzhub.org/study/parkinson-s-disease-alpha-synuclein-transgenic-mice-develop-neuronal-16399671

   … human alpha-syn and nitrated synuclein. Motor neurons were depleted (approximately 75%) in A53T mice but were affected less in A30P mice. Axonal degeneration was present in many regions. Electron microscopy confirmed the cell and …

4. Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formationResearch summary

   Research summaries · alzhub.org/study/nitration-of-tyrosine-10-critically-enhances-amyloid-aggregation-and-21903077

   … NO target, which is nitrated at tyrosine 10 (3NTyr(10)-Aβ). Nitration of Aβ accelerated its aggregation and was detected in the core of Aβ plaques of APP/PS1 mice and AD brains. NOS2 deficiency or oral treatment with the NOS2 …

5. Genetically encoding protein oxidative damageResearch summary

   Research summaries · alzhub.org/study/genetically-encoding-protein-oxidative-damage-18321101

   … that is homogeneously nitrated at a site known to be modified in disease-related inflammatory responses, and we measured the effect of this defined modification on protein function. Posttranslational modification of tyrosine …

6. Nitration of tau protein is linked to neurodegeneration in tauopathiesResearch summary

   Research summaries · alzhub.org/study/nitration-of-tau-protein-is-linked-to-neurodegeneration-in-tauopathies-12937143

   … n847, which recognizes nitrated tau and alpha-synuclein. n847 detected nitrated tau in the insoluble fraction of AD, corticobasal degeneration (CBD), and Pick's disease (PiD) brains by Western blots. Immunohistochemistry (IHC) …

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