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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 161–170, page 17 of 20. Filter these by subject, year and score in the research library →

1. PM2.5 exposure exacerbates Alzheimer's disease pathology through lysosomal dysfunction in APP/PS1 miceResearch summary

   Research summaries · alzhub.org/study/pm2-5-exposure-exacerbates-alzheimer-s-disease-pathology-through-40865239

   … dysfunction playing a core driving role. These findings not only provide new insights into the association between PM2.5 and AD but also lay a crucial theoretical foundation for the development of targeted preventive and …

2. Pathological angiogenesis was associated with cerebrovascular lesion and neurodegeneration in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/pathological-angiogenesis-was-associated-with-cerebrovascular-lesion-39777972

   Introduction We investigated the specific factors driving abnormal angiogenesis in Alzheimer's disease (AD) and its role in cerebrovascular lesions and neurodegeneration. Methods We assessed cerebrovascular pathologies, …

3. Anatomy and function of the fornix in the context of its potential as a therapeutic targetResearch summary

   Research summaries · alzhub.org/study/anatomy-and-function-of-the-fornix-in-the-context-of-its-potential-as-32132227

   … not yet known whether driving fornix activity can enhance cognition-optimal target and stimulation parameters to rescue memory deficits have yet to be determined. As the most prevalent cause of dementia, Alzheimer's disease (AD) …

4. Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 PathwayResearch summary

   Research summaries · alzhub.org/study/complement-c3-enhances-lps-elicited-neuroinflammation-and-37268807

   … neuroinflammation and in driving progressive neurodegeneration. We found that complement C3 is upregulated in lipopolysaccharide (LPS)-stimulated neuron/glial cultures. Mechanistic studies revealed that microglia-released …

5. Development of disease-modifying drugs for frontotemporal dementia spectrum disordersResearch summary

   Research summaries · alzhub.org/study/development-of-disease-modifying-drugs-for-frontotemporal-dementia-32203398

   … FTD pathogenesis is driving the development of potential disease-modifying therapies. Most of these drugs target pathological tau - this category includes tau phosphorylation inhibitors, tau aggregation inhibitors, active and …

6. Effects of sexual differentiation and APOE genotype on the development of Alzheimer-related pathology in female EFAD miceResearch summary

   Research summaries · alzhub.org/study/effects-of-sexual-differentiation-and-apoe-genotype-on-the-93b65e21

   … female bias of APOE4 in driving AD pathogenesis. Specifically, using the EFAD transgenic mouse model of AD that includes knock-in of human APOE3 or APOE4 , we examined the effects of experimental masculinization in perinatal …

7. Health Care Costs Associated With Hospice Use For People With Dementia In The USResearch summary

   Research summaries · alzhub.org/study/health-care-costs-associated-with-hospice-use-for-people-with-37669483

   … people with dementia is driving up costs. Yet this perspective fails to incorporate potential cost savings associated with hospice. We estimated the association between hospice use by people with dementia and health care costs, …

8. Inflammation in Neurological Disorders: The Thin Boundary Between Brain and PeripheryResearch summary

   Research summaries · alzhub.org/study/inflammation-in-neurological-disorders-the-thin-boundary-between-32143546

   … phenomenon sparking and driving the neuropathological processes. However, the upstream/downstream relationship between inflammatory events and neurological pathology is still unclear. Recent Advances: Solid recent evidence …

9. KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/kl-vs-heterozygosity-is-associated-with-lower-amyloid-dependent-tau-34158479

   … the key AD pathology driving neurodegeneration and cognitive decline, is unknown. Here, we assessed the interaction between KL-VS het and levels of beta-amyloid, a key driver of tau pathology, on the levels of PET-assessed …

10. Retinal Vasculopathy in Alzheimer's DiseaseResearch summary

    Research summaries · alzhub.org/study/retinal-vasculopathy-in-alzheimer-s-disease-34630020

    … and pivotal factors driving cognitive impairment in AD. Likewise, retinal vascular abnormalities such as changes in vessel density and fractal dimensions, blood flow, foveal avascular zone, curvature tortuosity, and …

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