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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 141–150, page 15 of 20. Filter these by subject, year and score in the research library →

1. Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/amyloid-a-immunotherapy-induced-microhemorrhages-are-linked-to-39434125

   … and vascular damage in driving the development of microhemorrhage. Conclusions In summary, our study has established a significant link between CAA-Aβ antibody immune complex formation, immune activation and vascular damage …

2. Clinical utility of office-based cognitive predictors of fitness to drive in persons with dementia: A systematic reviewResearch summary

   Research summaries · alzhub.org/study/clinical-utility-of-office-based-cognitive-predictors-of-fitness-to-17198485

   … address this gap are that driving researchers routinely perform cutoff score analyses and that stakeholder organizations (e.g., AMA, American Geriatrics Society) sponsor consensus fora to review driving research methodologies. …

3. Lecanemab: Wirksamkeit beruht auf dem Fc-Fragment des AntikörpersResearch summary

   Research summaries · alzhub.org/study/lecanemab-wirksamkeit-beruht-auf-dem-fc-fragment-des-antikorpers-0681bd63

   … investigate the mechanisms driving antibody-induced amyloid clearance, so the work is preclinical. Lecanemab ist eine Anti-Amyloid-Antikörper-Therapie, die entwickelt wurde, um toxische Amyloid-Plaques zu beseitigen und das …

4. Non-traditional socio-environmental and geospatial determinants of Alzheimer's disease-related dementia mortalityResearch summary

   Research summaries · alzhub.org/study/non-traditional-socio-environmental-and-geospatial-determinants-of-40424712

   … rather than urbanization driving the distribution. Conclusions Ambient air pollution interacts with SVI to influence ADRD mortality rates. Our findings support a role for non-traditional factors including elements of the built …

5. Out of Pocket Costs for People with Dementia: A Comparison Across Insurance TypesResearch summary

   Research summaries · alzhub.org/study/out-of-pocket-costs-for-people-with-dementia-a-comparison-across-51811bdb

   … types of healthcare driving out-of-pocket costs for people with dementia. We conducted a cohort study of PWD age 65+ in the Medicare Current Beneficiary Survey, 2002-2022. We categorized PWD based on 12 months of TM, MA, partial …

6. ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative DiseaseResearch summary

   Research summaries · alzhub.org/study/ros-generation-in-microglia-understanding-oxidative-stress-and-32823544

   … molecular mechanisms driving inflammatory-related NOX activation. Finally, we discuss recent evidence that therapeutic target identification should be unbiased and founded on relevant pathophysiological assays to facilitate the …

7. Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/single-nucleus-multi-omics-identifies-shared-and-distinct-pathways-in-41223260

   … critical regulatory changes driving disease progression, revealing potential therapeutic targets. Our comparative analyses uncovered disease-enriched noncoding regions and genome-wide transcription factor (TF) binding …

8. Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?Research summary

   Research summaries · alzhub.org/study/alzheimer-s-disease-beyond-amyloid-can-the-repetitive-failures-of-32247851

   … dementia targets are driving research in new directions bolstered by recent findings on the genetic, omics and systems biology associated with AD/dementia. In moving forward, lessons learnt from the amyloid debacle should be used …

9. Association between anosognosia and neuropsychiatric symptoms in Alzheimer’s disease dementia patientsResearch summary

   Research summaries · alzhub.org/study/association-between-anosognosia-and-neuropsychiatric-symptoms-in-41345521

   … underlying mechanisms driving these associations and to inform the development of targeted therapeutic strategies aimed at improving patient outcomes in this population. In this exploratory study, patients with Alzheimer's …

10. Disentangling Mitochondria in Alzheimer's DiseaseResearch summary

    Research summaries · alzhub.org/study/disentangling-mitochondria-in-alzheimer-s-disease-34768950

    … be the major factor driving AD, and currently, only symptomatic treatments are available. AD has a complex etiology, although mitochondrial dysfunction, oxidative stress, inflammation, and metabolic abnormalities have been widely …

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