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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 131–140, page 14 of 20. Filter these by subject, year and score in the research library →

1. Dysregulation of a novel autophagosome-mitochondria contact contributes to tauopathy-related neurodegeneration by disrupting autophagyResearch summary

   Research summaries · alzhub.org/study/dysregulation-of-a-novel-autophagosome-mitochondria-contact-42316849

   … a critical mechanism driving autophagy dysfunction and pathological MAPT/tau buildup in tauopathy neurons and highlight TBC1D15-modulated AV-Mito contact release and autophagy as promising therapeutic targets for tauopathies, …

2. Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brainResearch summary

   Research summaries · alzhub.org/study/elevated-risk-of-type-2-diabetes-for-development-of-alzheimer-disease-24949886

   … such as amyloid-beta driving reactive oxygen and nitrogen species. It is a mechanistic review, not a clinical trial, so it does not show that any treatment prevents or cures Alzheimer's disease. Aβ is associated with the …

3. Genome‐Wide Analysis of Memory, Language, and Executive Function Reveals Domain‐Specific Genetic Architecture in Alzheimer DiseaseResearch summary

   Research summaries · alzhub.org/study/genomewide-analysis-of-memory-language-and-executive-function-reveals-41442684

   … the distinct processes driving deficits in memory, language, and executive function. Such insights pave the way for more precise, syndrome-focused interventions, ultimately guiding a precision medicine approach tailored to the …

4. How many people will need palliative care in 2040? Past trends, future projections and implications for servicesResearch summary

   Research summaries · alzhub.org/study/how-many-people-will-need-palliative-care-in-2040-past-trends-future-28514961

   … one of the conditions driving palliative care need. Background Current estimates suggest that approximately 75% of people approaching the end-of-life may benefit from palliative care. Results By 2040, annual deaths in England …

5. Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosineResearch summary

   Research summaries · alzhub.org/study/linking-oxysterols-and-different-stages-of-mild-cognitive-impairment-40361183

   … and m6A methylation driving MCI progression warrants further mechanistic investigation. This study found altered oxysterols, gut metabolites, and m6A methylation in different stages of mild cognitive impairment, with some …

6. Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2Research summary

   Research summaries · alzhub.org/study/microglia-gravitate-toward-amyloid-plaques-surrounded-by-externalized-38981007

   … (AD); nonetheless, the driving force behind TREM2-mediated phagocytosis of beta-amyloid (Aβ) plaques remains unknown. Here, using advanced 2D/3D/4D co-culture systems with loss-of-function mutations in TREM2 (a frameshift …

7. Oral GLP-1 receptor agonist promotes astrocyte-neuron lactate and lipid transfer with neuroprotective effectsResearch summary

   Research summaries · alzhub.org/study/oral-glp-1-receptor-agonist-promotes-astrocyte-neuron-lactate-and-42330959

   … aerobic glycolysis and driving lactate release. Astrocyte-derived lactate is taken up by neurons and elevates histone H3 lysine 9 lactylation (H3K9la), which in turn facilitates lipid transport from neurons back to astrocytes. …

8. TDP-43 pathology effect on volume and flortaucipir uptake in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/tdp-43-pathology-effect-on-volume-and-flortaucipir-uptake-in-36463537

   … relevant contributor driving the volume-uptake mismatch in older AD participants. HIGHLIGHTS: TDP-43 pathology affects medial temporal volume loss but not tau radiotracer uptake. Greater TDP-43 pathology effect is seen in old age …

9. The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory abilityResearch summary

   Research summaries · alzhub.org/study/the-role-of-nlrp3-casp1-in-inflammasome-mediated-neuroinflammation-28318352

   … However, the mechanism driving these phenomena remains poorly understood. We demonstrate that Mn activates the NLRP3-CASP1 inflammasome pathway in the hippocampus of mice and BV2 cells by triggering autophagy-lysosomal …

10. Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trialResearch summary

    Research summaries · alzhub.org/study/aerobic-exercise-for-alzheimer-s-disease-a-randomized-controlled-28187125

    … may be important in driving brain benefits. Trial registration ClinicalTrials.gov NCT01128361. Aerobic exercise was associated with a modest gain in functional ability (Disability Assessment for Dementia) compared to individuals …

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