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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 121–130, page 13 of 20. Filter these by subject, year and score in the research library →

1. Patient‐derived forebrain cortical organoids reveal biphasic tau–MAP6–microtubule axis dysfunction in tauopathyResearch summary

   Research summaries · alzhub.org/study/patientderived-forebrain-cortical-organoids-reveal-biphasic-42411568

   … tau-MAP6-microtubule mechanism driving tauopathy and establishes these organoids as a platform for phase-specific therapy. In patient-derived brain organoids, early-phase tau mutant tissue showed elevated tau and hyperdynamic …

2. Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson's diseaseResearch summary

   Research summaries · alzhub.org/study/peripheral-innate-immune-and-bacterial-signals-relate-to-clinical-32006615

   … of the components and driving mechanisms involved and their relationship with clinical heterogeneity and progression to dementia remain poorly explored. We examined changes in peripheral innate immune-related markers in PD cases …

3. Sex and gender differences in Alzheimer's disease: current challenges and implications for clinical practice: Position paper of the Dementia and Cognitive Disorders Panel of the European Academy of NeurologyResearch summary

   Research summaries · alzhub.org/study/sex-and-gender-differences-in-alzheimer-s-disease-current-challenges-32056347

   … identifying factors driving variability that can be used for patient stratification. In addition to genetic and lifestyle factors, the individual's sex and gender are emerging as crucial drivers of phenotypic variability. …

4. The burden of disease in older people and implications for health policy and practiceResearch summary

   Research summaries · alzhub.org/study/the-burden-of-disease-in-older-people-and-implications-for-health-25468153

   … population ageing is driving the worldwide epidemic of chronic diseases, substantial untapped potential exists to modify the relation between chronological age and health. This objective is especially important for the most …

5. Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/alpha-synuclein-co-pathology-is-associated-with-accelerated-amyloid-40098057

   … tau pathology thereby driving faster cognitive decline. This highlights that a-Syn co-pathology may specifically accelerate amyloid-driven tau pathophysiology in AD, underscoring the need to consider αSyn in AD research and …

6. Dysfunctional microglia and tau pathology in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/dysfunctional-microglia-and-tau-pathology-in-alzheimer-s-disease-36302379

   … malfunctioning microglia in driving tau propagation. This review discusses the recent reports on the contribution of microglial cells to the development and progression of tau pathology. The detailed study of pathogenic …

7. Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegenerationResearch summary

   Research summaries · alzhub.org/study/interferon-a-master-cytokine-in-microglia-mediated-neural-network-36283867

   … IFN-γ is pivotal for driving Toll-like receptor (TLR)-activated microglia into neurotoxic phenotypes that induce energetic and oxidative stress, severe network dysfunction, and neuronal death. Pharmacological targeting of …

8. Interplay between Brain Pericytes and Endothelial Cells in DementiaResearch summary

   Research summaries · alzhub.org/study/interplay-between-brain-pericytes-and-endothelial-cells-in-dementia-34329605

   … crosstalk is a major driving force in dementia pathology. Disruption of the BBB in dementia precipitates cognitive decline. This review highlights how dysfunction of the endothelial-pericyte crosstalk contributes to dementia, …

9. Simulation of Alzheimer's diagnostic flows with blood biomarker test options in JapanResearch summary

   Research summaries · alzhub.org/study/simulation-of-alzheimer-s-diagnostic-flows-with-blood-biomarker-test-41070364

   … because of lower costs, driving higher demand for testing. HIGHLIGHTS: A dynamic simulation models Alzheimer's diagnostic workflows in Japan.Blood biomarker (BBM) tests reduce diagnostic wait times for Alzheimer's in …

10. Affective Computing for Late-Life Mood and Cognitive DisordersResearch summary

    Research summaries · alzhub.org/study/affective-computing-for-late-life-mood-and-cognitive-disorders-35002802

    … vocal biomarkers, and driving and behavior can provide objective biomarkers for early identification and monitoring, allow more comprehensive understanding of daily life and disease fluctuations, and facilitate an understanding …

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