28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The review focuses on the clinical diagnostic utility of transcranial magnetic stimulation (TMS). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Arterial spin labeling (ASL) is a magnetic resonance (MR) imaging technique used to assess cerebral blood flow noninvasively by magnetically labeling inflowing blood. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recent studies suggest that a complex, distributed neural network underpins semantic cognition. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Tobacco smoke consists of thousands of compounds including nicotine. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The Notch signalling pathway is evolutionarily conserved and is crucial for the development and homeostasis of most tissues. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The treatment of epileptic seizure disorders is not restricted to the achievement of seizure-freedom, but must also include the management of comorbid medical, neurological, psychiatric and cognitive comorbidities. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous system. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Defining the multiple roles of the mechanistic (formerly 'mammalian') target of rapamycin (mTOR) signalling pathway in neurological diseases has been an exciting and rapidly evolving story of bench-to-bedside translational research that has spanned gene mutation discovery, functional experimental validation of mutations, pharmacological pathway manipulation, and clinical trials. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Each year, 10 million people worldwide survive the neurologic injury associated with a stroke. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The aims of this study were to estimate the incidence of acute confusional state (ACS), its predisposing factors and consequences in 111 consecutive patients operated for fractured neck of the femur. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Excitotoxicity, defined as excessive exposure to the neurotransmitter glutamate or overstimulation of its membrane receptors, has been implicated as one of the key factors contributing to neuronal injury and death in a wide range of both acute and chronic neurologic disorders. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Nitric oxide (NO) is a unique biological messenger molecule which mediates diverse physiologic roles. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
We analyze the relationship between age of survival, morbidity, and disability among centenarians (age 100-104 years), semisupercentenarians (age 105-109 years), and supercentenarians (age 110-119 years). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Low-to-moderate red wine consumption appeared to reduce age-related neurological disorders including macular degeneration, stroke, and cognitive deficits with or without dementia. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Agitation and aggression are frequently occurring and distressing behavioral and psychological symptoms of dementia (BPSD). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
L-Glutamate serves as a major excitatory neurotransmitter in the mammalian central nervous system (CNS) and is stored in synaptic vesicles by an uptake system that is dependent on the proton electrochemical gradient (VGLUTs). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cytokines and chemokines have been implicated in contributing to the initiation, propagation and regulation of immune and inflammatory responses. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Breakdown of cellular membranes is a characteristic feature of neuronal degeneration in acute (stroke) and chronic (senile dementia) neurological disorders. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glutamate is an essential neurotransmitter regulating brain functions. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
In just under 20 years the kynurenine family of compounds has developed from a group of obscure metabolites of the essential amino acid tryptophan into a source of intensive research, with postulated roles for quinolinic acid in neurodegenerative disorders, most especially the AIDS-dementia complex and Huntington's disease. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Microvascular disease, not macroscopic infarction, was the chief substrate of vascular dementia in this series of cases. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Magnetic resonance tractography based on diffusion-tensor imaging was first introduced to the medical imaging community a decade ago. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Ginkgo shows promise in treating some of the neurologic sequelae associated with Alzheimer's disease, TBI, stroke, normal aging, edema, tinnitus, and macular degeneration. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
In recent years, oxidative stress has been implicated in a variety of degenerative processes, diseases, and syndromes. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →