28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Dementias are a varied group of disorders typically associated with memory loss, impaired judgment and/or language and by symptoms affecting other cognitive and social abilities to a degree that interferes with daily functioning. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
One of the shared hallmarks of neurodegenerative diseases is the accumulation of misfolded proteins. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Impairment of the ubiquitin-proteasome system (UPS) has been implicated in the pathogenesis of a wide variety of neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cellular proteomes are continuously undergoing alterations as a result of new production of proteins, protein folding, and degradation of proteins. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The research on aging and age-related diseases, especially the neurodegenerative diseases, is on the fast track. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Impaired protein degradation has been discussed as a cause or consequence of various neurodegenerative diseases, such as Alzheimer's, Parkinson's and Huntington's disease. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cells have developed an evolutionary obligation to survey and maintain proteome fidelity and avoid the possible toxic consequences of protein misfolding and aggregation. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The extracellular aggregation of proteins into proteotoxic oligomers and amyloid fibrils is implicated in the onset and pathology of numerous diseases referred to as amyloid diseases. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The autophagic process is the only known mechanism for mitochondrial turnover and it has been speculated that dysfunction of autophagy may result in mitochondrial error and cellular stress. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A theoretical definition of caregiver stress is provided, and the defining attributes, related concepts, antecedents, and consequences of caregiver stress are proposed, and case studies are presented. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Random effects results suggest that caregiver burden weakens the inverse relationship between health utilities and institutional service use, leading to greater likelihood of institutional use than would be expected at a given level of health. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Due to the rapid increase of the number in people with dementia, social costs of dementia are also expected to rise. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Family caregivers of patients with frontotemporal dementia identify behavioral disturbances as most troubling. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
SAS PROC MIXED analysis showed burden to be associated with caregiver age, length of time involved in caregiving, custodial units, involvement in hands-on care, and expectations for care. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The purpose of this study was to examine the relationship between spiritual well-being and caregiver burden in family caregivers of persons with Alzheimer's disease. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The association between caregiver's stress and depressive symptoms, and sociodemographic and clinical characteristics of Alzheimer's patients and caregivers was evaluated in 63 primary caregivers consecutively recruited at the Alzheimer's Dementia Research and Care Unit of Brescia, northern Italy. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Psychotic/behavioral, depressive and minimally symptomatic clusters differed for caregiver burden and lack of insight. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Care home residents are often frail with multiple comorbidities and cognitive impairment, most commonly caused by dementia. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research on the impact of the built environment in long-term care settings continues to grow. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
You have been called to the emergency room to evaluate an elderly nursing home patient sent for consultation who has ischemic gangrene of the right foot. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This article examines transitions between the community and nursing homes among the private pay and the Medicaid eligible older (65+) persons. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Principles of diffusion of innovation were used to change care provided to people with dementia in 9 nursing homes. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Change in quality of life was better in facilities that used a specialized worker approach, trained more staff in more domains central to dementia care, and encouraged activity participation. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Case management for persons with dementia may increase use of community-based services and delay nursing home admission. 5 key findings →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →