28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Abeta peptide accumulation is thought to be the primary event in the pathogenesis of Alzheimer's disease (AD), with downstream neurotoxic effects including the hyperphosphorylation of tau protein. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Unlike the proposed "polypill", EFAs are endogenous molecules present in almost all tissues, have no significant or few side effects, can be taken orally for long periods of time even by pregnant women, lactating mothers, and infants, children, and adults; and have been known to reduce the incidence cardiovascular diseases including stroke. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glutamate is the primary excitatory neurotransmitter in the mammalian brain. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The frailty syndrome has recently attracted attention of the scientific community and public health organizations as precursor and contributor of age-related conditions (particularly disability) in older persons. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Brain function critically depends on a close matching between metabolic demands, appropriate delivery of oxygen and nutrients, and removal of cellular waste. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Reactive oxygen species (ROS) are metabolic byproducts that are necessary for physiological function but can be toxic at high levels. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The findings in this report indicate that progress has been steady but slow for many of the priority health issues in the United States. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's disease (AD) and Parkinson's disease (PD) are devastating, frequent, and still incurable neurodegenerative diseases that manifest as cognitive and motor disorders. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
High fat diet-induced obesity is associated with insulin resistance (IR) and other chronic, diet related illnesses, including dementia. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sharp wave ripples (SPW-Rs) represent the most synchronous population pattern in the mammalian brain. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Endoplasmic reticulum (ER) dysfunction might have an important part to play in a range of neurological disorders, including cerebral ischaemia, sleep apnoea, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, the prion diseases, and familial encephalopathy with neuroserpin inclusion bodies. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Dietary and metabolic therapies have been attempted in a wide variety of neurological diseases, including epilepsy, headache, neurotrauma, Alzheimer disease, Parkinson disease, sleep disorders, brain cancer, autism, pain, and multiple sclerosis. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The lymphatic clearance pathways of the brain are different compared to the other organs of the body and have been the subject of heated debates. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The endoplasmic reticulum(ER) is a multifunctional organelle within which protein folding, lipid biosynthesis, and calcium storage occurs. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD) are widespread and disabling. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sleep disturbance in AD is associated with other behavioural symptoms, notably aggressiveness. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Essential tremor (ET) is a syndrome of tremor in posture and movement, but recent studies have revealed additional cerebellar motor disturbances, cognitive disturbances, personality changes, hearing loss, and olfactory deficits. 3 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
Age-related hearing loss (ARHL) has a multifactorial pathogenesis and it is an inevitable hearing impairment associated with reduction of communicative skills related to ageing. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The large majority of oldest old subjects had multimorbidity. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Hearing deficits associated with cognitive impairment have attracted much recent interest, motivated by emerging evidence that impaired hearing is a risk factor for cognitive decline. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Hearing loss has been associated with cognitive decline in the elderly and is considered to be an independent risk factor for dementia. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The present review is focused on juvenile neuronal ceroid lipofuscinosis (JNCL; Batten disease) due to a mutation in CLN3 . 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Age-related hearing loss (ARHL) -presbycusis - is the most prevalent neurodegenerative disease and number one communication disorder of our aged population; and affects hundreds of millions of people worldwide. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
These data confirm earlier reports of a substantial number of treatable eye diseases, particularly advanced cataract, in nursing home residents, and indicate a need for increased surveillance of these communities. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Obesity leads to chronic, systemic inflammation and can lead to insulin resistance (IR), β-cell dysfunction, and ultimately type 2 diabetes (T2D). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →