27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
During a mean follow-up of 3.9 years, dementia was documented in 193 (6.3%) of the 3051 randomized participants in the actively treated group and 217 (7.1%) of the 3054 randomized participants in the placebo group (relative risk reduction, 12% [95% confidence interval, -8% to 28%]; P =.2). 4 key findings →
Participants: 6,105 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Median follow-up increased from 2.0 years in the double-blind trial to 3.9 years overall. 2 key findings →
Participants: 1,485 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
The use of donepezil produced statistically significant improvements in ADAS-cog, CIBIC plus, and Mini-Mental State Examination scores, relative to placebo. 2 key findings →
Design: clinical trial Participants: 468 Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Low levels of vitamin D were associated with substantial cognitive decline in the elderly population studied over a 6-year period, which raises important new possibilities for treatment and prevention. 5 key findings →
Participants: 858 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
During follow-up 319 participants developed dementia (221 had AD). 4 key findings →
Design: cohort study Participants: 2,288 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Delirium is frequent among older ICU patients. 1 key finding →
Design: cohort study Participants: 304 Evidence: moderate
Full summary, score breakdown and related studies → Original source
These results should be confirmed with a randomized clinical trial of a centrally active ACE inhibitor in the prevention of cognitive decline and dementia. 5 key findings →
Participants: 1,054 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Loss of motor function is a common consequence of aging, but little is known about the factors that predict idiopathic motor decline. 4 key findings →
Design: cohort study Participants: 906 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Three randomized controlled trials (RCTs) and 6 single-case designs (SCDs; N of 1 trials) met inclusion criteria. 4 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
This study suggests that estrogen replacement therapy may be useful for preventing or delaying the onset of Alzheimer disease in postmenopausal women. 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
During the 18-year follow-up (4184.8 risk-years), 93 participants were diagnosed as having dementia. 2 key findings →
Participants: 93 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Delirium occurred in 239 (9%) of 2721 observations or 131 (16%) of 797 patients. 5 key findings →
Participants: 797 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
In this large, population-based cohort, baseline and long-term average serum total cholesterol levels were not associated with the risk for incident AD. 3 key findings →
Participants: 1,026 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
During the 6534 person-years of follow-up (mean, 5.02 years per person), 440 subjects were diagnosed as having dementia, including 333 with Alzheimer disease. 3 key findings →
Participants: 1,301 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Exposure to ACH medications is independently and specifically associated with a subsequent increase in delirium symptom severity in elderly medical inpatients with diagnosed delirium. 3 key findings →
Design: longitudinal study Participants: 278 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
There are specific risk factors associated with feeding tube placement in nursing home residents with severe cognitive impairment. 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Older persons with hip fractures remain at increased risk of subsequent hip fractures. 4 key findings →
Participants: 481 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Elderly people taking anticholinergic drugs were at increased risk for cognitive decline and dementia. 5 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
In this large cohort, heavy smoking in midlife was associated with a greater than 100% increase in risk of dementia, AD, and VaD more than 2 decades later. 5 key findings →
Participants: 5,367 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Serious events, as indicated by a hospital admission or death, are frequent following the short-term use of antipsychotic drugs in older adults with dementia. 2 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Individuals with DS have a substantially increased risk of mortality due to specific causes and may have an elevated risk of other incident cancers in addition to leukemia. 4 key findings →
Participants: 22 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
Use of cholinesterase inhibitors is associated with increased rates of syncope, bradycardia, pacemaker insertion, and hip fracture in older adults with dementia. 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Between September 1, 1990, and August 31, 2005, 69 subjects experienced nontraumatic hip or vertebral fractures. 3 key findings →
Participants: 919 Evidence: moderate
Full summary, score breakdown and related studies → Original source Full text may need a subscription
This study confirms that healthy senior citizens as well as senior citizens with underlying medical conditions are at risk for the serious complications of influenza and benefit from vaccination. 2 key findings →
Participants: 20,000 Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
A predictive model based on 5 risk factors has been successfully validated for prediction of delirium at discharge in hospitalized older patients. 2 key findings →
Participants: 58 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →