27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
= 0.01). We also found that greater use of emotion-focused coping and deriving greater gains in caregiving mitigated the negative association between caregiver financial difficulty and their distress and perception of PwSDs' well-being. 2 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Physicians have a responsibility to recognize caregiver burden. 3 key findings →
Design: meta-analysis Evidence: high
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Health care expenditures among persons with dementia were substantially larger than those for other diseases, and many of the expenses were uncovered (uninsured). 1 key finding →
Design: retrospective cohort Participants: 1,702 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
We identified 19 studies with primary data. 4 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Recommendations for practice include development of standardized guidelines that address caregiver assessment, education, and resources; identification of "caregiver champions" in practice settings; provision of referrals to established support organizations for caregivers (eg, Cancer Support Community, Cancer Care); and collaboration among caregiving, professional, and cancer-related organizations to advocate policy and practice changes for family caregivers. 1 key finding →
Design: meta-analysis Evidence: high
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There is little evidence that interventions aimed at supporting and/or providing information to carers of people with dementia are uniformly effective. 2 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
This JAMA clinical review synthesizes cohort studies and meta-analyses to give physicians practical guidance on recognizing, assessing, and treating caregiver burden. 4 key findings →
Design: systematic-review Evidence: moderate
Full summary, score breakdown and related studies → Original source
High blood pressure is one of the most important risk factors for ischaemic heart disease, stroke, other cardiovascular diseases, chronic kidney disease and dementia. 5 key findings →
Evidence: low
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Much can still be done in the way of service development and provision, GP training and education, and the eradication of stigma attached to dementia, to improve the early detection and management of dementia. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The results of this review highlight the significant economic burden of dementia for patients, families and healthcare systems and thus are important for future health policy planning. 5 key findings →
Design: systematic review Evidence: high
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Purpose of study To assess trends in family caregiving between 1999 and 2015. 2 key findings →
Evidence: low
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Caregivers of care recipients without dementia or disability accounted for the largest absolute number of helpers. 2 key findings →
Evidence: low
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The following strategies helped with implementation of decisions: introducing change slowly; organising legal changes for the carer as well as the patient; involving a professional to persuade the patient to accept services; and emphasising that services optimised, not impeded, independence. 1 key finding →
Evidence: low
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The results showed that 68.02% of caregivers were highly burdened and 65% exhibited depressive symptoms. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Caregiver characteristics and provision of caregiving tasks determine caregiver burden more than care recipient characteristics. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Primary care is the ideal setting for early detection of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (ADRD), as it serves as the primary point of care for most older adults. 5 key findings →
Evidence: low
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Due to the ageing population throughout the world, the rates of older adults suffering from dementia are increasing, requiring a closer look at this population. 1 key finding →
Design: meta-analysis Evidence: high
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Family caregivers of people with dementia, often called the invisible second patients, are critical to the quality of life of the care recipients. 1 key finding →
Evidence: low
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Alzheimer's disease (AD) is the most common cause of dementia worldwide. 2 key findings →
Evidence: low
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The results in this study demonstrated that the Zarit Burden Interview is a valid and reliable instrument for measuring the burden of caregivers of PWD in Singapore. 2 key findings →
Participants: 149 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Dementia was significantly associated with caregiver burden related to emotional difficulty (odds ratio [OR] = 2.04; 95% confidence interval [CI], 1.34-3.09) and physical difficulty (OR = 1.67, 95% CI, 1.01-2.78), but not financial difficulty. 3 key findings →
Participants: 1,419 Evidence: low
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In total, 3028 posts were retrieved, including 1552 from older adult-related subreddits and 1476 from Alzheimer disease-related subreddits; 18 key topics were identified, with the most frequent topics being expressing feelings (2178/3028, 71.93%) and seeking advice and support (1982/3028, 65.46%). 5 key findings →
Evidence: low
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Three overarching concepts were identified: "Pathways to Preparedness'", 'Multi-Level Barriers', and 'Bridging the Gap.' 5 key findings →
Participants: 13 Evidence: low
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It appears that changes in the patients' behavior and in the interpersonal relations between caregivers and patients are associated with caregiver depression. 4 key findings →
Participants: 94 Evidence: low
Full summary, score breakdown and related studies → Original source
Whether there is a difference in impact between EOD and LOD on caregivers is still unclear. 3 key findings →
Evidence: low
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Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →