27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Relative to HC, the participants with cTBI had lower CAC (0.10 ± 0.03 vs 0.12 ± 0.03 mm 2 /mm Hg, P = .046) and higher CVR (0.17 ± 0.03 vs 0.15 ± 0.03 mm Hg/mL/min, P = .028). 4 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source
Epilepsy is highly prevalent in people with intellectual disabilities. 1 key finding →
Design: systematic review Participants: 48 Evidence: high
Full summary, score breakdown and related studies → Original source
We demonstrated that peripherin is distributed in sciatic nerve, and to a lesser extent spinal cord tissue lysates, but not in brain or extra-neural tissues. 3 key findings →
Design: longitudinal study Participants: 45 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Traumatic brain injury (TBI) is one of the leading causes of injury-related death. 2 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
To review the evidence for risk factors of Creutzfeldt-Jakob disease (CJD), we pooled and reanalyzed the raw data of three case-control studies. 4 key findings →
Design: case-control study Participants: 178 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Thirty full-text articles met the eligibility criteria. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Using the best available data, our survey of a limited number of disorders shows that the burden of neurologic illness affects many millions of people in the United States. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
In this prospective, population-based study the prevalence of iNPH was 3.7% among individuals 65 years and older, and more common in the higher age group, 80 years and above. 2 key findings →
Participants: 117 Evidence: low
Full summary, score breakdown and related studies → Original source
Multivariate analyses assessed the strength of association of comorbid conditions with epilepsy as compared with the general population. 3 key findings →
Participants: 49,000 Evidence: low
Full summary, score breakdown and related studies → Original source
We have investigated the extent and pattern of immunostaining for ubiquitin protein (UBQ) in 60 patients with frontotemporal lobar degeneration (FTLD) with ubiquitin-positive, tau-negative inclusions (FTLD-U), 37 of whom were ascertained in Manchester UK and 23 in Newcastle-Upon-Tyne, UK. 1 key finding →
Participants: 60 Evidence: low
Full summary, score breakdown and related studies → Original source
In a convenience sample of deceased football players who donated their brains for research, a high proportion had neuropathological evidence of CTE, suggesting that CTE may be related to prior participation in football. 3 key findings →
Participants: 27 Evidence: low
Full summary, score breakdown and related studies → Original source
A total of 169 patients in Tibet (high altitude) and 310 patients in Beijing (low altitude) were enrolled. 5 key findings →
Participants: 169 Evidence: low
Full summary, score breakdown and related studies → Original source
The present patients with positive GFAP-immunoglobulin G are highly similar to autoimmune GFAP astrocytopathy, described in a recent report. 3 key findings →
Participants: 19 Evidence: low
Full summary, score breakdown and related studies → Original source
We conducted virus-isolation studies on 56 specimens from the nervous system of 45 patients in order to determine whether human T-cell lymphotropic virus Type III (HTLV-III) is directly involved in the pathogenesis of the neurologic disorders frequently encountered in the acquired immunodeficiency syndrome (AIDS) and the AIDS-related complex. 2 key findings →
Participants: 45 Evidence: low
Full summary, score breakdown and related studies → Original source
As the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Our new NfL ELISA showed a good analytical performance (inter-plate coefficient of variation (CV) < 13%), with no cross-reactivity with neurofilament medium and heavy (NfM and NfH). 5 key findings →
Participants: 97 Evidence: low
Full summary, score breakdown and related studies → Original source
We have defined a new paraneoplastic immunoglobulin G (IgG) autoantibody specific for CRMP-5, a previously unknown 62-kd neuronal cytoplasmic protein of the collapsin response-mediator family. 2 key findings →
Participants: 121 Evidence: low
Full summary, score breakdown and related studies → Original source
Our findings support an association between neuroaxonal injury and delirium. 3 key findings →
Participants: 130 Evidence: low
Full summary, score breakdown and related studies → Original source
There have been 87 cases of superficial siderosis of the CNS reported in the world literature and 63 cases had developed the clinical syndrome with sufficient details to be reviewed. 1 key finding →
Participants: 22 Evidence: low
Full summary, score breakdown and related studies → Original source
In order to define the histopathological substrate of the dementia that frequently complicates the acquired immune deficiency syndrome (AIDS), we analyzed the neuropathological findings in 70 autopsied adult AIDS patients, 46 of whom had suffered clinically overt dementia. 3 key findings →
Participants: 23 Evidence: low
Full summary, score breakdown and related studies → Original source
The prevalence ratio of many common psychiatric and somatic conditions is increased in adults with epilepsy who consult a primary care physician in the U.K. These findings may have implications in the diagnosis and management of epilepsy and coexisting conditions, as well as in health care provision. 3 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
Conductance to outflow of CSF was measured in a prospective study of 80 patients with normal pressure hydrocephalus. 3 key findings →
Participants: 80 Evidence: low
Full summary, score breakdown and related studies → Original source
The cause of progressive supranuclear palsy (PSP) is not known and has been little studied. 4 key findings →
Participants: 75 Evidence: low
Full summary, score breakdown and related studies → Original source
The coexistence of cerebrovascular disease leading to deep white matter infarction and normal-pressure hydrocephalus has been noted previously in clinical studies, as both diseases can present with the triad of gait disturbance, dementia, and incontinence. 5 key findings →
Participants: 20 Evidence: low
Full summary, score breakdown and related studies → Original source
Lower levels of NFL, NG, Aβ42, and t-tau were found in patients with iNPH versus SIVD, while YKL-40 and p-tau were similar in the two diseases. 4 key findings →
Participants: 28 Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →