39/100
In these models, PM2.5 concentration was associated with smaller left hippocampal volume. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
39/100
Alzheimer's disease (AD), an aging-related neurodegenerative disease, is a major cause of dementia in the elderly. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The third part of the DGP statement introduces the current body of knowledge on less studied health outcomes associated with exposure to ambient air pollution: the negative impact on metabolism leading to impaired glucose tolerance and diabetes as well as contribution to the development of neurodegenerative disorders and delayed cognitive function in children. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
As one of the most harmful air pollutants, fine particulate matter (PM2.5) has been implicated as a risk factor for multiple diseases, which has generated widespread public concern. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
38/100
Poisoning from pesticides is a global public health problem and accounts for nearly 300,000 deaths worldwide every year. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Pesticides are a family of compounds which have brought many benefits to mankind in the agricultural, industrial, and health areas, but their toxicities in both humans and animals have always been a concern. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recent extensive evidence indicates that air pollution, in addition to causing respiratory and cardiovascular diseases, may also negatively affect the brain and contribute to central nervous system diseases. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The central nervous system is emerging as an important target for adverse health effects of air pollution, where it may contribute to neurodevelopmental and neurodegenerative disorders. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Air pollution is an important cause of non-communicable diseases globally with particulate matter (PM) as one of the main air pollutants. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
PM2.5 particles in air pollution have been widely considered associated with respiratory and cardiovascular diseases. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
In this article the neurotoxic disorders appearing in patients exposed to organophosphorus pesticides and known mechanisms involved are reviewed. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The purpose of this review is to describe recent clinical and epidemiological studies examining the adverse effects of urban air pollution on the central nervous system (CNS). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Exposure to ambient air pollution and noise is ubiquitous globally. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white matter volume in older adults, specifically for particulate matter <2.5-μm diameter (PM 2.5 ). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Airborne particulate matter poses a serious threat to human health. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Millions of children and young adults are exposed to fine particulate matter (PM2.5) and ozone, associated with Alzheimer's disease (AD) risk. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Pesticides are widely-used chemicals commonly applied in agriculture for the protection of crops from pests. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Neurodegenerative disorders are typically sporadic in nature in addition to usually influenced through an extensive range of environmental factors, lifestyle, and genetic elements. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
There is growing evidence that air pollution is a risk factor for a number of neurodegenerative diseases, most notably Alzheimer's (AD) and Parkinson's (PD). 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Increasing evidence points to an association of airborne pollutant exposure with respiratory, cardiovascular, and neurological pathology. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Organophosphorus (OP) compounds have been known as the most widely used pesticides during the past half century and there have been a huge body of literature regarding their association with human chronic diseases. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Traffic-related air pollution particulate matter (TRAP-PM) is associated with increased risk of Alzheimer Disease (AD). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Fewer than 5% of Alzheimer's disease (AD) cases are demonstrably directly inherited, indicating that environmental factors may be important in initiating and/or promoting the disease. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
As the median age of the population increases, the number of individuals with Alzheimer's disease (AD) and the associated socio-economic burden are predicted to worsen. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
From across this tag
9 of the 239 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Fine Particulate Matter Exposure and Cerebrospinal Fluid Markers of Vascular Injury
- Causal association between particulate matter 2.5 and Alzheimer's disease: a Mendelian randomization study
- Impact of air pollution on depression and suicide
- Neurobehavioral effects of long-term exposure to pesticides: results from the 4-year follow-up of the PHYTONER Study
- Hypertension and Stroke as Mediators of Air Pollution Exposure and Incident Dementia
- Particulate air pollution from different emission sources, cognitive performance, and cognitive declines in India
- Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer's Disease
- Prefrontal white matter pathology in air pollution exposed Mexico City young urbanites and their potential impact on neurovascular unit dysfunction and the development of Alzheimer's disease
- Impacts of Climate Change and Air Pollution on Neurologic Health, Disease, and Practice: A Scoping Review
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →