27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
The mean age of the 402 study residents was 86.7 years [range, 67-102 years]; 350 were white (87.1%) and 323 were female (80.3%), with DNH directives that by 6 months did not differ between arms (63% in both arms; adjusted odds ratio [AOR], 1.08; 95% CI, 0.69-1.69). 1 key finding →
Participants: 212 Evidence: high
Full summary, score breakdown and related studies → Original source
Residents' mean age was 86.5 years, 39 (12.9%) were African American, and 246 (81.5%) were women. 1 key finding →
Evidence: high
Full summary, score breakdown and related studies → Original source
Most proxies select comfort as the preferred level of care for NH residents with advanced dementia. 5 key findings →
Participants: 402 Evidence: high
Full summary, score breakdown and related studies → Original source
Better alignment between preferences for comfort-focused care and advance directives is needed in advanced dementia. 2 key findings →
Participants: 328 Evidence: high
Full summary, score breakdown and related studies → Original source
Specialty palliative care consultation for hospitalized patients with late-stage dementia is feasible and promising to improve decision-making and some treatment outcomes. 1 key finding →
Design: randomized controlled trial Participants: 62 Evidence: high
Full summary, score breakdown and related studies → Original source
Of 4267 participants with probable dementia in HRS, the mean (SD) age was 82.2 (7.6) years, 2930 (survey-weighted 69.4%) were female, and 785 (survey-weighted 12.1%) identified as Black. 1 key finding →
Design: cohort study Participants: 2,404 Evidence: moderate
Full summary, score breakdown and related studies → Original source
A risk score based on 12 variables from the MDS estimates 6-month mortality for nursing home residents with advanced dementia with greater accuracy than existing prognostic guidelines. 5 key findings →
Design: cohort study Participants: 6,799 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Surgical repair of a hip fracture was associated with lower mortality among NH residents with advanced dementia and should be considered together with the residents' goals of care in management decisions. 2 key findings →
Design: cohort study Participants: 2,441 Evidence: moderate
Full summary, score breakdown and related studies → Original source
A mortality risk score derived from MDS data predicted six-month survival in advanced dementia with moderate accuracy. 1 key finding →
Design: cohort study Participants: 22,405 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Most families chose comfort as the primary GOC. 4 key findings →
Participants: 302 Evidence: low
Full summary, score breakdown and related studies → Original source
Persons dying with advanced dementia admitted to nursing homes have different characteristics compared to those admitted to home care services. 3 key findings →
Design: cohort study Participants: 2,730 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Questionably beneficial medications are common in advanced dementia, even as death approaches. 5 key findings →
Design: cohort study Participants: 323 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Residence in an SCU is associated with some, but not all, markers of better quality end-of-life care among nursing home residents with advanced dementia. 3 key findings →
Design: longitudinal study Participants: 43 Evidence: moderate
Full summary, score breakdown and related studies → Original source
When prospectively validated at the bedside and used as a continuous measure, the ability of the ADEPT score to identify nursing home residents with advanced dementia at high risk of death within 6 months was modest, albeit better than hospice eligibility guidelines. 1 key finding →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
A minority of NH residents with advanced dementia received hospice care. 3 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
The original mortality risk score predicted 6-month mortality with reasonable accuracy in 2 validation cohorts of nursing home residents with advanced dementia. 2 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
HCPs of NH patients with advanced dementia can most commonly expect to encounter medical decisions relating to feeding problems, infections, and pain. 5 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
For most institutionalized persons with advanced dementia, a decision to forgo hospitalization is not made until death is imminent. 5 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Pneumonia is a common terminal event in advanced dementia for which many patients receive parenteral antibiotics. 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Residents dying with advanced dementia who received SNF care in the last 90 days of life had fewer aggressive treatments and lower odds of hospital death if they also received hospice care at any point during that time. 3 key findings →
Design: retrospective cohort Evidence: moderate
Full summary, score breakdown and related studies → Original source
Most NH residents who use statins at the time of progression to advanced dementia continue use in follow-up. 5 key findings →
Participants: 1,699 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The majority of hospitalizations of NH residents with advanced dementia were due to infections and thus were potentially avoidable, because infections are often treatable in the NH. 5 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Despite the growing number of persons with advanced dementia, and the need to improve their end-of-life care, few studies have addressed this important topic. 2 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
The sources of stress for families of nursing home (NH) residents with advanced dementia have not been well described. 1 key finding →
Design: prospective cohort Evidence: moderate
Full summary, score breakdown and related studies → Original source
Our findings support need for greater ACP discussions between patients and proxies. 3 key findings →
Design: cross-sectional Participants: 14 Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →