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Home › Research › Topics › precursor

precursor

1,346 studies tagged precursor, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,346 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Annals of neurology 2015-07-28 Genetics

    Targeted sequencing of confirmed GWAS loci revealed an excess burden of deleterious coding mutations in LOAD, with the greatest burden observed in ABCA7 and BIN1.

  2. Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Scientific reports 2015-07-23 TREM2 and immune genetics

    Previous studies have evaluated gene expression in Alzheimer's disease (AD) brains to identify mechanistic processes, but have been limited by the size of the datasets studied.

  3. De novo deleterious genetic variations target a biological network centered on Aβ peptide in early-onset Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular psychiatry 2015-07-21 Risk genes beyond APOE

    We hypothesized that de novo variants (DNV) might participate in the genetic determinism of sporadic early-onset Alzheimer disease (EOAD, onset before 65 years).

  4. Role of apolipoprotein E in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuropsychiatric disease and treatment 2015-07-16 Prevention and risk

    Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system.

  5. Amyloid precursor protein metabolism and inflammation markers in preclinical Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Neurology 2015-07-15 Genetics

    Our findings suggest that inflammation in the CNS increases in normal aging and is intimately related to markers of neurodegeneration in the preclinical stages of AD and SNAP. sAPPβ and β-secretase activity are not useful diagnostic or staging markers in preclinical AD.

  6. New suggestive genetic loci and biological pathways for attention function in adult attention-deficit/hyperactivity disorder

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015-07-14 Genetics

    Attention deficit is one of the core symptoms of the attention-deficit/hyperactivity disorder (ADHD).

  7. Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD)

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of nature and science 2015-07-01 TREM2 and immune genetics

    According to the ' amyloid cascade hypothesis of Alzheimer's disease ' first proposed about 16 years ago, the accumulation of Aβ peptides in the human central nervous system (CNS) is the primary influence driving Alzheimer's disease (AD) pathogenesis, and Aβ peptide accretion is the result of an imbalance between Aβ peptide production and clearance.

  8. Oxidative stress in Alzheimer disease and mild cognitive impairment: evidence from human data provided by redox proteomics

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Archives of toxicology 2015-07-01 Mild cognitive impairment

    Alzheimer disease (AD) is a neurodegenerative disease with many known pathological features, yet there is still much debate into the exact cause and mechanisms for progression of this degenerative disorder.

  9. Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. The Lancet. Neurology 2015-06-30 Genetics

    It was one of the genes most strongly associated with risk of Alzheimer's disease in a Belgian cohort.

  10. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2015-06-10 Getting a diagnosis

    Levels of autolysosomal proteins in neurally derived blood exosomes distinguish patients with AD from case controls and appear to reflect the pathology of AD up to 10 years before clinical onset.

  11. APOEε2 is associated with milder clinical and pathological Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Annals of neurology 2015-06-01 Genetics

    Even when adjusted for age at onset, symptom duration, and other demographic variables, APOEε2 is associated with milder AD pathology and less severe antemortem cognitive impairment compared to APOEε3 and ε4 alleles, suggesting a relative neuroprotective effect of APOEε2 in AD.

  12. Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2015-05-27 Risk genes beyond APOE

    Alzheimer disease (AD) is characterized by amyloid-β accumulation, with soluble oligomers (Aβo) being the most synaptotoxic.

  13. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Biochimica et biophysica acta 2015-05-21 Prevention and risk

    Global obesity is a pandemic status, estimated to affect over 2 billion people, that has resulted in an enormous strain on healthcare systems worldwide.

  14. Beta-amyloid deposition in chronic traumatic encephalopathy

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Acta neuropathologica 2015-05-06 Disease mechanisms

    Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with repetitive mild traumatic brain injury.

  15. Age, Sex, and APOE ε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. JAMA neurology 2015-05-01 Biomarkers

    Overall, memory worsened from age 30 years through the 90s. The HVa worsened gradually from age 30 years to the mid-60s and more steeply beyond that age.

  16. Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 84 out of 100. JAMA 2015-05-01 Genetics

    Among persons without dementia, the prevalence of cerebral amyloid pathology as determined by positron emission tomography or cerebrospinal fluid findings was associated with age, APOE genotype, and presence of cognitive impairment.

  17. Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. European journal of nuclear medicine and molecular imaging 2015-04-17 Biomarkers

    The findings provide further in vivo evidence that astrocytosis occurs early in AD, preceding Aβ plaque deposition.

  18. Redox proteomics identification of specifically carbonylated proteins in the hippocampi of triple transgenic Alzheimer's disease mice at its earliest pathological stage

    ✓ Peer-reviewed alzhub usefulness score 35 out of 100. Journal of proteomics 2015-04-15 Digital health tools

    Alzheimer's disease (AD) is the most common cause of dementia in the elderly population.

  19. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Circulation 2015-04-10 Genetics

    By conditioning on the genetic association with the cardiovascular phenotypes, we identify novel AD susceptibility loci, including 2 genome-wide significant variants conferring increased risk for AD.

  20. Organotypic vibrosections from whole brain adult Alzheimer mice (overexpressing amyloid-precursor-protein with the Swedish-Dutch-Iowa mutations) as a model to study clearance of beta-amyloid plaques

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in aging neuroscience 2015-04-09 Biomarkers

    Alzheimer's disease is a severe neurodegenerative disorder of the brain, pathologically characterized by extracellular beta-amyloid plaques, intraneuronal Tau inclusions, inflammation, reactive glial cells, vascular pathology and neuronal cell death.

  21. Oxidative stress involving changes in Nrf2 and ER stress in early stages of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biochimica et biophysica acta 2015-04-06 Mild cognitive impairment

    Oxidative stress and endoplasmic reticulum (ER) stress have been associated with Alzheimer's disease (AD) progression.

  22. Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Journal of biological chemistry 2015-03-26 Biomarkers

    Alzheimer disease (AD) is characterized neuropathologically by synaptic disruption, neuronal loss, and deposition of amyloid β (Aβ) protein in brain structures that are critical for memory and cognition.

  23. Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Brain : a journal of neurology 2015-03-23 Getting a diagnosis

    Second, we examined the relevance of Thal amyloid phase in a prospectively-followed autopsied cohort who underwent ante-mortem (11)C-Pittsburgh compound B imaging; using the large autopsy cohort to broaden our perspective of (11)C-Pittsburgh compound B results.

  24. Amyloid-β, anxiety, and cognitive decline in preclinical Alzheimer disease: a multicenter, prospective cohort study

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. JAMA psychiatry 2015-03-01 Genetics

    Although the presence of abnormal levels of amyloid-β (Aβ) is associated with higher rates of progression to clinically classified mild cognitive impairment or dementia, little research has evaluated potentially modifiable moderators of Aβ-related cognitive decline, such as anxiety and depressive symptoms.

  25. Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2015-03-01 Risk genes beyond APOE

    The mechanisms that contribute to selective vulnerability of the magnocellular basal forebrain cholinergic neurons in neurodegenerative diseases, such as Alzheimer's disease, are not fully understood.

  26. Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of neurochemistry 2015-02-26 Mild cognitive impairment

    The clinical symptoms of Alzheimer disease (AD) include a gradual memory loss and subsequent dementia, and neuropathological deposition of senile plaques and neurofibrillary tangles.

  27. Spatially distinct atrophy is linked to β-amyloid and tau in preclinical Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Neurology 2015-02-25 Brain scans and imaging

    Spatially distinct neurodegeneration is associated with Aβ and tau pathology in preclinical AD.

  28. Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Brain : a journal of neurology 2015-02-11 Mild cognitive impairment

    Cross-sectional functional magnetic resonance imaging studies using a memory task in patients with mild cognitive impairment have produced discordant results, with some studies reporting increased hippocampal activity--consistent with findings in genetic at-risk populations--and other studies reporting decreased hippocampal activity, relative to normal controls.

  29. Coding mutations in SORL1 and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Annals of neurology 2015-02-01 Risk genes beyond APOE

    Common single nucleotide polymorphisms in the SORL1 gene have been associated with late onset Alzheimer disease (LOAD), but causal variants have not been fully characterized nor has the mechanism been established.

  30. Downregulated miR-29c correlates with increased BACE1 expression in sporadic Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. International journal of clinical and experimental pathology 2015-02-01 Risk genes beyond APOE

    Beta-site Amyloid precursor protein Cleaving Enzyme 1 (BACE1) is conceived as a potential target for therapies against Alzheimer disease (AD) which is characterized by the accumulation of plaques formed of short β-amyloid (APPβ) peptides.

  31. Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2015-02-01 Risk genes beyond APOE

    Elevation of both neuronal iron and nitric oxide (NO) in the substantia nigra are associated with Parkinson's disease (PD) pathogenesis.

  32. Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Neuron 2015-01-22 Genetics

    The impact of inflammation suppressor pathways on Alzheimer's disease (AD) evolution remains poorly understood.

  33. Plasma levels of apolipoprotein E and risk of dementia in the general population

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Annals of neurology 2015-01-13 Genetics

    Low plasma levels of apoE are associated with increased risk of future Alzheimer disease and all dementia in the general population, independent of ε2/ε3/ε4 APOE genotype.

  34. Association of Alzheimer's disease GWAS loci with MRI markers of brain aging

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Neurobiology of aging 2015-01-06 Genetics

    Whether novel risk variants of Alzheimer's disease (AD) identified through genome-wide association studies also influence magnetic resonance imaging-based intermediate phenotypes of AD in the general population is unclear.

  35. Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Acta neuropathologica 2015-01-03 Disease mechanisms

    Alzheimer's disease (AD) is the most common form of dementia in the elderly.

  36. Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. JAMA neurology 2015-01-01 Genetics

    Brain DNA methylation in multiple AD loci is associated with AD pathologies.

  37. Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. JAMA neurology 2014-12-01 Risk factors

    Patients with moderate to severe AD presented with higher mean (SD) orexin levels compared with controls (154.36 [28.16] vs 131.03 [26.55]; P Conclusions and relevance Our results demonstrate that, in AD, increased cerebrospinal fluid orexin levels are related to a parallel sleep deterioration, which appears to be associated with cognitive decline.

  38. Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Acta neuropathologica 2014-11-29 Risk genes beyond APOE

    The key role of APP in the pathogenesis of Alzheimer disease is well established.

  39. APOE, MAPT, and SNCA genes and cognitive performance in Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. JAMA neurology 2014-11-01 Genetics

    Our data indicate that the APOE ε4 allele is an important predictor of cognitive function in PD across multiple domains.

  40. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. JAMA neurology 2014-11-01 Genetics

    Analysis confirmed the association of APOE with earlier AAO (P = 3.3 × 10(-96)), with associations in CR1 (rs6701713, P = 7.2 × 10(-4)), BIN1 (rs7561528, P = 4.8 × 10(-4)), and PICALM (rs561655, P = 2.2 × 10(-3)) reaching statistical significance (P Conclusions and relevance We confirmed an association of APOE (OMIM 107741) variants with AAO among affected participants with LOAD and observed novel associations of CR1 (OMIM 120620), BIN1 (OMIM 601248), and PICALM (OMIM 603025) with AAO.

  41. Fibrin deposited in the Alzheimer's disease brain promotes neuronal degeneration

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurobiology of aging 2014-10-31 Inflammation and the immune system

    Alzheimer's disease (AD) is the most common form of dementia and has no effective treatment.

  42. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014-10-23 Getting a diagnosis

    Insulin resistance causes diminished glucose uptake in similar regions of the brain in Alzheimer's disease (AD) and type 2 diabetes mellitus (DM2).

  43. The emerging link between O-GlcNAc and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 2014-10-21 Risk genes beyond APOE

    Regional glucose hypometabolism is a defining feature of Alzheimer disease (AD).

  44. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The Journal of biological chemistry 2014-09-24 Risk genes beyond APOE

    Pathogenic mutations in the amyloid precursor protein (APP) gene have been described as causing early onset familial Alzheimer disease (AD).

  45. The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2014-09-24 Risk genes beyond APOE

    Missense mutations in alanine 673 of the amyloid precursor protein (APP), which corresponds to the second alanine of the amyloid β (Aβ) sequence, have dramatic impact on the risk for Alzheimer disease; A2V is causative, and A2T is protective.

  46. Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. PLoS medicine 2014-09-16 Genetics

    Although altered lipid metabolism has been extensively implicated in the pathogenesis of Alzheimer disease (AD) through cell biological, epidemiological, and genetic studies, the molecular mechanisms linking cholesterol and AD pathology are still not well understood and contradictory results have been reported.

  47. Influence of microglial activation on neuronal function in Alzheimer's and Parkinson's disease dementia

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-09-16 Inflammation and the immune system

    Alzheimer's disease (AD) and Parkinson's disease (PD) are the two common neurodegenerative diseases characterized by progressive neuronal dysfunction in the presence of pathological microglial activation.

  48. Amyloid-β pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Journal of biological chemistry 2014-09-12 Genetics

    Previous data demonstrate that bexarotene (Bex), retinoid X receptor (RXR) agonist, reduces soluble and insoluble amyloid-β (Aβ) in Alzheimer disease (AD)-transgenic mice either by increasing the levels of mouse apolipoprotein E (apoE) or increasing ABCA1/ABCG1-induced apoE lipoprotein association/lipidation.

  49. Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-09-10 Long-term cohort studies

    Plasma amyloid-β (Aβ) peptide levels have been examined as a low-cost accessible marker for risk of incident Alzheimer's disease (AD) and dementia, but results have varied between studies.

  50. Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurobiology of aging 2014-09-06 TREM2 and immune genetics

    In this study, we have assessed the expression and splicing status of genes involved in the pathogenesis or affecting the risk of Alzheimer's disease (AD) in the postmortem inferior temporal cortex samples obtained from 60 subjects with varying degree of AD-related neurofibrillary pathology.

From across this tag

9 of the 1,344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts