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283 results for "driving".

Research summaries 260

Showing the best 200 of 260, 81–90, page 9 of 20. Filter these by subject, year and score in the research library →

  1. Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's diseaseResearch summary

    Research summaries · alzhub.org/study/multi-tissue-neocortical-transcriptome-wide-association-study-33947463

    … common genetic variants driving differences in transcript expression that confer AD risk is necessary to elucidate AD mechanism and develop therapeutic interventions. We modify the FUSION transcriptome-wide association study …

  2. Neighborhood disadvantage and dementia incidence in a cohort of Asian American and non‐Latino White older adults in Northern CaliforniaResearch summary

    Research summaries · alzhub.org/study/neighborhood-disadvantage-and-dementia-incidence-in-a-cohort-of-asian-35388625

    … different mechanisms driving dementia incidence in these groups could inform dementia prevention efforts. Among non-Latino White older adults, living in a more disadvantaged neighborhood was linked to a slightly higher rate of …

  3. Pathways to Racial/Ethnic Inequalities in DementiaResearch summary

    Research summaries · alzhub.org/study/pathways-to-racial-ethnic-inequalities-in-dementia-39805030

    … and unique mechanisms driving inequalities across minoritized groups, where research is lacking. This health inequality reflects structural racism, which creates and sustains racial differences in social determinants of health, …

  4. Role of NLRP3 inflammasome-mediated neuronal pyroptosis and neuroinflammation in neurodegenerative diseasesResearch summary

    Research summaries · alzhub.org/study/role-of-nlrp3-inflammasome-mediated-neuronal-pyroptosis-and-37725102

    … explore the mechanisms driving NLRP3 activation and assembly, as well as the post-translational modifications regulating NLRP3 inflammasome activation. Understanding these mechanisms will contribute to a deeper understanding of …

  5. Secular trends in cognitive trajectories of diverse older adultsResearch summary

    Research summaries · alzhub.org/study/secular-trends-in-cognitive-trajectories-of-diverse-older-adults-31672483

    … part of the mechanisms driving secular trends in cognitive aging and dementia. Later birth year was associated with higher initial cognitive levels for Whites and Blacks, but not Hispanics. Later birth year was also associated …

  6. Simulation of Alzheimer's diagnostic flows with blood biomarker test options in JapanResearch summary

    Research summaries · alzhub.org/study/simulation-of-alzheimer-s-diagnostic-flows-with-blood-biomarker-test-41070364

    … because of lower costs, driving higher demand for testing. HIGHLIGHTS: A dynamic simulation models Alzheimer's diagnostic workflows in Japan.Blood biomarker (BBM) tests reduce diagnostic wait times for Alzheimer's in …

  7. Single-cell RNA sequencing-derived signatures define response patterns to atezolizumab + bevacizumab in advanced hepatocellular carcinomaResearch summary

    Research summaries · alzhub.org/study/single-cell-rna-sequencing-derived-signatures-define-response-39709141

    … underlying cellular processes driving clinical benefit vs. resistance to atezo+bev. Methods We harnessed the power of single-cell RNA sequencing in advanced HCC to derive gene expression signatures recapitulating 21 cell …

  8. TDP-43 pathology effect on volume and flortaucipir uptake in Alzheimer's diseaseResearch summary

    Research summaries · alzhub.org/study/tdp-43-pathology-effect-on-volume-and-flortaucipir-uptake-in-36463537

    … relevant contributor driving the volume-uptake mismatch in older AD participants. HIGHLIGHTS: TDP-43 pathology affects medial temporal volume loss but not tau radiotracer uptake. Greater TDP-43 pathology effect is seen in old age …

  9. The Gut-Brain Axis in Alzheimer’s Disease: Microbiota as a Key Contributor to Disease PathogenesisResearch summary

    Research summaries · alzhub.org/study/the-gut-brain-axis-in-alzheimers-disease-microbiota-as-a-key-918169a2

    … of AD pathogenesis, driving neuroinflammation, and amyloid and tau pathology through the microbiota–gut–brain axis. This review synthesizes current findings on the mechanistic pathways by which alterations in gut microbiota …

  10. The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUSResearch summary

    Research summaries · alzhub.org/study/the-key-role-of-solvent-in-condensation-mapping-water-in-liquid-33515602

    … solvent as a thermodynamic driving force. The FUS concentration inside LLPS droplets was determined to be increased to 2.0 mM independent of the initial protein concentration (5 or 10 μM solutions) by fluorescence measurements. …

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