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199 results for "antipsychotic".

Research summaries 180

Showing 11–20, page 2 of 18. Filter these by subject, year and score in the research library →

1. Effect of second-generation antipsychotics on caregiver burden in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/effect-of-second-generation-antipsychotics-on-caregiver-burden-in-21939611

   … improved with atypical antipsychotic treatment. Objective Data from the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) trial were used to evaluate the effect of atypical antipsychotics …

2. A double-blind randomized placebo-controlled withdrawal trial comparing memantine and antipsychotics for the long-term treatment of function and neuropsychiatric symptoms in people with Alzheimer's disease (MAIN-AD)Research summary

   Research summaries · alzhub.org/study/a-double-blind-randomized-placebo-controlled-withdrawal-trial-25523285

   … options are limited to antipsychotics, which carry extensive safety issues. There is emerging evidence to support the potential benefits of memantine, currently licensed for moderate to severe AD, in the prophylaxis of …

3. Abrupt discontinuation and tapering of antipsychotics in older adults with dementia: a target trial emulation studyResearch summary

   Research summaries · alzhub.org/study/abrupt-discontinuation-and-tapering-of-antipsychotics-in-older-adults-42302797

   Guidelines recommend limiting antipsychotic treatment to short-term use ( Methods Using UK primary care data from the Clinical Practice Research Datalink, linked with hospital and mortality data from Jan 1, 1998, to March 31, …

4. Antipsychotics, other psychotropics, and the risk of death in patients with dementia: number needed to harmResearch summary

   Research summaries · alzhub.org/study/antipsychotics-other-psychotropics-and-the-risk-of-death-in-patients-25786075

   Importance Antipsychotic medications are associated with increased mortality in older adults with dementia, yet their absolute effect on risk relative to no treatment or an alternative psychotropic is unclear. Objective To …

5. Nursing homes underreport antipsychotic prescribingResearch summary

   Research summaries · alzhub.org/study/nursing-homes-underreport-antipsychotic-prescribing-30724582

   Nursing homes underreport their antipsychotic prescribing levels, on average, by 1 percentage point per quarter relative to Medicare Part D claims (0.013, 95% confidence interval (CI), 0.012-0.015; p<.001). After the Medicare …

6. The antipsychotic discontinuation in Alzheimer disease trial: clinical rationale and study designResearch summary

   Research summaries · alzhub.org/study/the-antipsychotic-discontinuation-in-alzheimer-disease-trial-clinical-21407047

   … Given the warnings about antipsychotic use in patients with dementia, studies of this type are essential to determine the optimal duration of treatment that confers the greatest benefit to risk ratio and to improve evidence-based …

7. Antipsychotic Initiation Among Older Dementia Patients Using Cholinesterase Inhibitors: A National Retrospective Cohort StudyResearch summary

   Research summaries · alzhub.org/study/antipsychotic-initiation-among-older-dementia-patients-using-33763822

   … galantamine users initiated antipsychotics. The mean time to antipsychotic initiation among patients who received antipsychotics was 109.29 ± 69.72 days for donepezil users, 96.70 ± 71.60 days for rivastigmine users, and 104.15 ± …

8. Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: a systematic review and network meta-analysisResearch summary

   Research summaries · alzhub.org/study/safety-of-pharmacologic-interventions-for-neuropsychiatric-symptoms-32546202

   … pharmacologic alternatives to antipsychotics are gaining in popularity, but randomized trial (RCT) data of their comparative safety is scarce. Results Our systematic review included 209 randomized and non-randomized studies …

9. The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/the-effectiveness-of-atypical-antipsychotics-for-the-treatment-of-16437455

   Analysis included patients treated with an atypical antipsychotic, compared with placebo Main results Sixteen placebo controlled trials have been completed with atypical antipsychotics although only nine had sufficient data to …

10. Trends in antipsychotic use in dementia 1999-2007Research summary

    Research summaries · alzhub.org/study/trends-in-antipsychotic-use-in-dementia-1999-2007-21300946

    Context Use of atypical antipsychotics for neuropsychiatric symptoms of dementia increased markedly in the 1990s. Concerns about their use began to emerge in 2002, and in 2005, the US Food and Drug Administration warned that use …

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