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287 results for "driving".

Research summaries 264

Showing the best 200 of 264, 121–130, page 13 of 20. Filter these by subject, year and score in the research library →

1. Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptidesResearch summary

   Research summaries · alzhub.org/study/pyroglutamate-formation-influences-solubility-and-amyloidogenicity-of-19518051

   … FBD, and FDD. The main driving force for the aggregation is apparently an increase in the hydrophobicity and thus an accelerated seed formation. The far-UV CD spectroscopic analysis points toward an enhanced beta-sheet structure …

2. ROS Generation in Microglia: Understanding Oxidative Stress and Inflammation in Neurodegenerative DiseaseResearch summary

   Research summaries · alzhub.org/study/ros-generation-in-microglia-understanding-oxidative-stress-and-32823544

   … molecular mechanisms driving inflammatory-related NOX activation. Finally, we discuss recent evidence that therapeutic target identification should be unbiased and founded on relevant pathophysiological assays to facilitate the …

3. Review: modulating factors in amyloid-beta fibril formationResearch summary

   Research summaries · alzhub.org/study/review-modulating-factors-in-amyloid-beta-fibril-formation-10940230

   … and understanding the driving forces behind these interactions as well as the structural motifs necessary for these interactions will help to elucidate potential sites that may be targeted to prevent amyloid formation and its …

4. Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced NeurodegenerationResearch summary

   Research summaries · alzhub.org/study/tau-pathology-drives-diseaseassociated-astrocyte-reactivity-in-39853966

   … pathology and A1R signaling, driving DAA-like astrocyte reactivity. Targeting the Tau-A1R axis may provide a novel therapeutic strategy for reducing HSD-induced neuroinflammation and cognitive deficits. In mice on a high-salt …

5. Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brainResearch summary

   Research summaries · alzhub.org/study/tau-covariance-patterns-in-alzheimer-s-disease-patients-match-31077982

   … through neural networks, driving neurodegeneration We found a striking convergence between [ 18 F]flortaucipir covariance patterns and intrinsic connectivity maps (range Spearman rho's: 0.32–0.78, p < .001), which corresponded …

6. Tau protein aggregation is associated with cellular senescence in the brainResearch summary

   Research summaries · alzhub.org/study/tau-protein-aggregation-is-associated-with-cellular-senescence-in-the-30126037

   … secondary mechanisms are driving toxicity. Transcriptomic analyses of NFT-containing neurons microdissected from postmortem AD brain revealed an expression profile consistent with cellular senescence. This complex stress response …

7. The Filamin A Proteomic Switch: Solubility States and Cytoskeletal Dynamics Explain the Inverse Epidemiological Relationship Between Cancer and Alzheimer’s DiseaseResearch summary

   Research summaries · alzhub.org/study/the-filamin-a-proteomic-switch-solubility-states-and-cytoskeletal-da7070f6

   … active motility engine driving invasive lamellipodia but stalls proteolytic processing and forces an absolute loss of the nuclear FLNA-90 tumor-suppressor brake, unleashing uninhibited c-Myc oncogenic transcription. Crucially, …

8. The influence of cognitive decline on the severity and quantity of drug-drug interactionsResearch summary

   Research summaries · alzhub.org/study/the-influence-of-cognitive-decline-on-the-severity-and-quantity-of-eec99df9

   … rather than independently driving DDI risk, with polypharmacy emerging as the principal modifiable determinant. Conclusions Medication burden, rather than cognitive status, was the key determinant of DDI risk, supporting daily …

9. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditionsResearch summary

   Research summaries · alzhub.org/study/trem2-promotes-anti-inflammatory-responses-in-microglia-and-is-32959884

   … Trem2 was important for "driving a number of the genes up-regulated in the anti-inflammatory phenotype." This is laboratory and animal work and does not establish a treatment, cure or prevention for Alzheimer's disease. We have …

10. A longitudinal study of age-related traits and cognitive function: The Collaborative Amish Aging and Memory Project (CAAMP)Research summary

    Research summaries · alzhub.org/study/a-longitudinal-study-of-age-related-traits-and-cognitive-function-the-1633fa73

    … and biological factors driving cognitive outcomes alongside other age-related conditions, advancing our understanding of both disease risk and protection. This describes an ongoing long-term study of nearly 4,000 Amish …

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