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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 31–40, page 4 of 20. Filter these by subject, year and score in the research library →

1. Effects of Alzheimer's disease and mild cognitive impairment on driving ability: a controlled clinical study by simulated driving testResearch summary

   Research summaries · alzhub.org/study/effects-of-alzheimer-s-disease-and-mild-cognitive-impairment-on-18615781

   … (MCI) on simulated car driving ability. Methods Twenty patients with a probable AD of mild severity (Clinical Dementia Rating, CDR = 1) were compared with 20 subjects with MCI (CD = 0.5), and a group of age-matched neurologically …

2. Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegenerationResearch summary

   Research summaries · alzhub.org/study/systematic-review-and-meta-analysis-of-human-transcriptomics-reveals-33347974

   … expression signature driving pathophysiology across these clinically and pathologically diverse proteinopathies. To test this hypothesis, we performed a systematic review of human CNS transcriptomics datasets from AD, LBD, and …

3. p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)Research summary

   Research summaries · alzhub.org/study/p53-is-a-central-regulator-driving-neurodegeneration-caused-by-33482083

   The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a GGGGCC repeat expansion in the C9orf72 gene. We developed a platform to interrogate the chromatin accessibility landscape …

4. Endo-lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?Research summary

   Research summaries · alzhub.org/study/endo-lysosomal-and-autophagic-dysfunction-a-driving-factor-in-28027395

   Alzheimer's disease (AD) is the most common cause of dementia, and its prevalence will increase significantly in the coming decades. Although important progress has been made, fundamental pathogenic mechanisms as well as most …

5. Chromatin activity at GWAS loci identifies T cell states driving complex immune diseasesResearch summary

   Research summaries · alzhub.org/study/chromatin-activity-at-gwas-loci-identifies-t-cell-states-driving-31548716

   Immune-disease-associated variants are enriched in active chromatin regions of T cells and macrophages. However, whether these variants function in specific cell states is unknown. Here we stimulated T cells and macrophages in …

6. Mild cognitive impairment and everyday function: an investigation of driving performanceResearch summary

   Research summaries · alzhub.org/study/mild-cognitive-impairment-and-everyday-function-an-investigation-of-19196629

   … include decrements in driving skills. We compared 46 participants with MCI to 59 cognitively normal controls on a driving evaluation conducted by a driving rehabilitation specialist who was blinded to participants' MCI …

7. Does inflammatory bowel disease play a role in cognitive decline? A systematic reviewResearch summary

   Research summaries · alzhub.org/study/does-inflammatory-bowel-disease-play-a-role-in-cognitive-decline-a-42172661

   … underlying mechanisms driving this association remain poorly understood and population, clinical and experimental studies show controversial results. Among others, factors such as chronic inflammation, gut-brain axis dysfunction, …

8. Inflammation in Alzheimer disease: driving force, bystander or beneficial response?Research summary

   Research summaries · alzhub.org/study/inflammation-in-alzheimer-disease-driving-force-bystander-or-16960575

   … a possible cause or driving force of Alzheimer disease. If true, this could have important implications for the development of new treatments. Alternatively, inflammation could simply be a byproduct of the disease process and may …

9. Examination of cognitive and instrumental functional performance as indicators for driving cessation risk across 3 yearsResearch summary

   Research summaries · alzhub.org/study/examination-of-cognitive-and-instrumental-functional-performance-as-19139253

   … functional performance in driving cessation while simultaneously accounting for any contributions of demographics, vision, physical performance, and health among a sample of older adults without dementia. Design and methods …

10. Attention and driving performance in Alzheimer's diseaseResearch summary

    Research summaries · alzhub.org/study/attention-and-driving-performance-in-alzheimer-s-disease-9520930

    … attention measures and driving performance in healthy older adults and individuals with very mild and mild dementia of the Alzheimer type (DAT). Subjects were administered an on-road driving assessment and three visual attention …

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