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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 171–180, page 18 of 20. Filter these by subject, year and score in the research library →

1. The Effectiveness of Vitamin E Treatment in Alzheimer's DiseaseResearch summary

   Research summaries · alzhub.org/study/the-effectiveness-of-vitamin-e-treatment-in-alzheimer-s-disease-30781638

   … hypocholesterolemic properties, driving to its importance for brain health. Moreover, the levels of vitamin E in Alzheimer's disease patients are lower than in non-demented controls. Thus, vitamin E could be a good candidate to …

2. The key role of solvent in condensation: Mapping water in liquid-liquid phase-separated FUSResearch summary

   Research summaries · alzhub.org/study/the-key-role-of-solvent-in-condensation-mapping-water-in-liquid-33515602

   … solvent as a thermodynamic driving force. The FUS concentration inside LLPS droplets was determined to be increased to 2.0 mM independent of the initial protein concentration (5 or 10 μM solutions) by fluorescence measurements. …

3. An Alternative View of Familial Alzheimer's Disease GeneticsResearch summary

   Research summaries · alzhub.org/study/an-alternative-view-of-familial-alzheimer-s-disease-genetics-37718800

   … amyloid-β peptide (Aβ) in driving Alzheimer's disease pathogenesis. Instead, increased activity of the βCTF (C99) fragment of AβPP is the critical pathogenic determinant altered by mutations in the APP gene. This model is …

4. Blood-Brain Barrier Disruption Is an Early Event That May Persist for Many Years After Traumatic Brain Injury in HumansResearch summary

   Research summaries · alzhub.org/study/blood-brain-barrier-disruption-is-an-early-event-that-may-persist-for-26574669

   … TBI, but the mechanisms driving post-TBI neurodegeneration remain elusive. Increasingly, blood-brain barrier (BBB) disruption has been recognized in a range of neurologic disorders including dementias, but little is known of the …

5. CSF ferritin in the clinicopathological progression of Alzheimer's disease and associations with APOE and inflammation biomarkersResearch summary

   Research summaries · alzhub.org/study/csf-ferritin-in-the-clinicopathological-progression-of-alzheimer-s-36357168

   Background A putative role for iron in driving Alzheimer's disease (AD) progression is complicated by previously reported associations with neuroinflammation, apolipoprotein E and AD proteinopathy. To establish how iron interacts …

6. Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer’s DiseaseResearch summary

   Research summaries · alzhub.org/study/computational-approaches-for-supporting-combination-therapy-in-the-80f66de5

   … informed neuronal circuits driving functional clinical readouts. Informed by data-driven approaches this knowledge-driven modeling could systematically and quantitatively simulate all possible target combinations for a maximal …

7. Discovery and Optimization of Tau Targeted Protein Degraders Enabled by Patient Induced Pluripotent Stem Cells-Derived Neuronal Models of TauopathyResearch summary

   Research summaries · alzhub.org/study/discovery-and-optimization-of-tau-targeted-protein-degraders-enabled-35317195

   … as primary models for driving a medicinal chemistry campaign around tau targeting degrader series. Our screening goal was to establish structure-activity relationships (SAR) for the different chemical series to identify the …

8. Early activation of cellular stress and death pathways caused by cytoplasmic TDP-43 in the rNLS8 mouse model of ALS and FTDResearch summary

   Research summaries · alzhub.org/study/early-activation-of-cellular-stress-and-death-pathways-caused-by-37012334

   … components are critical for driving disease onset and neurodegeneration in ALS and FTD. We studied the rNLS8 transgenic mouse model, which expresses human TDP-43 with a genetically-ablated nuclear localisation sequence within …

9. Lifespace metrics of older adults with mild cognitive impairment and dementia recorded via geolocation dataResearch summary

   Research summaries · alzhub.org/study/lifespace-metrics-of-older-adults-with-mild-cognitive-impairment-and-34698431

   … metrics and concurrent driving status and anteceding scores on the sit-to-stand test (at baseline and follow-up). Conclusions Further longitudinal exploration of lifespace is required to develop an understanding of the nature of …

10. Towards Combinatorial Approaches for Preserving Cognitive Fitness in AgingResearch summary

    Research summaries · alzhub.org/study/towards-combinatorial-approaches-for-preserving-cognitive-fitness-in-30343822

    … ultimately converge in driving neurotrophic signaling. Considering recent technological advances, several interventions apart from cognitive enhancing drugs, including noninvasive brain stimulation, physical exercise/vascular …

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