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315 results for "driving".

Research summaries 292

Showing the best 200 of 292, 101–110, page 11 of 20. Filter these by subject, year and score in the research library →

1. C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC ‐Derived Microglia and Modulates Glial‐Neuronal CrosstalkResearch summary

   Research summaries · alzhub.org/study/c9orf72-repeat-expansion-induces-metabolic-dysfunction-in-human-ipsc-40888599

   … role of microglia in driving metabolic dysregulation and intercellular crosstalk in ALS pathogenesis and suggest that targeting metabolic pathways in immune cells may provide new therapeutic avenues. In cell models from C9orf72 …

2. Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tauResearch summary

   Research summaries · alzhub.org/study/cell-autonomous-microglia-defects-in-a-stem-cell-model-of-40527900

   … cells like microglia in driving disease pathophysiology. Here, we demonstrate that MAPT mRNA and tau protein are expressed in microglia in human brains and in human induced pluripotent stem cell (iPSC)-derived microglia like …

3. Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)Research summary

   Research summaries · alzhub.org/study/clonal-hematopoiesis-of-indeterminate-potential-chip-in-40214958

   … same aging processes driving large artery atherosclerosis in CHIP carriers also impair small vessels, including the cerebral microvasculature. While the role of CHIP in large vessel disease is well-documented, its specific …

4. Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisResearch summary

   Research summaries · alzhub.org/study/converging-mechanisms-in-als-and-ftd-disrupted-rna-and-protein-23931993

   … cell-to-cell prion-like spread driving progression. It is a mechanistic proposal about these two diseases, not a treatment, cure or prevention for Alzheimer's disease. Breakthrough discoveries identifying common genetic causes …

5. Current advances and unmet needs in Alzheimer's disease trials for individuals with Down syndrome: Navigating new therapeutic frontiersResearch summary

   Research summaries · alzhub.org/study/current-advances-and-unmet-needs-in-alzheimer-s-disease-trials-for-40528298

   … universal AD risk in DS is driving a stronger focus on tailored clinical research. Ongoing and forthcoming studies, including TRC-DS, ABATE, HERO, ALADDIN, and LESS-AD, are beginning to address these gaps. Beyond …

6. Ginsenoside Rc mitigates hippocampal neuronal damage and cognitive impairment in vascular dementia rats via the pY705-Stat3/Foxo3a and pS727-Stat3/GRIM-19 pathwaysResearch summary

   Research summaries · alzhub.org/study/ginsenoside-rc-mitigates-hippocampal-neuronal-damage-and-cognitive-41268317

   … targeting Stat3 and driving its dual-phosphorylation. Through the pY705-Stat3/Foxo3a and pS727-Stat3/GRIM-19 pathways, GRc alleviated hippocampal neuronal apoptosis and synaptic dysfunction, thereby improving cognitive function …

7. Neuroimaging Compendium of Microglia, Amyloid, Tau, and Neurodegeneration Across Clinical Variants of Alzheimer DiseaseResearch summary

   Research summaries · alzhub.org/study/neuroimaging-compendium-of-microglia-amyloid-tau-and-41288284

   … patterns of amyloid and tau driving symptomatology, but the distribution of microglia density, as measured by 18kDa translocator protein (TSPO) PET, is unknown. Baseline TSPO, amyloid, and tau PET as well as T1 MRI from the …

8. Protein misfolding and its dual role in neurodegeneration and cancer progressionResearch summary

   Research summaries · alzhub.org/study/protein-misfolding-and-its-dual-role-in-neurodegeneration-and-cancer-41309196

   … protein misfolding, driving degeneration in neurons while supporting proliferation in tumors, underscores its centrality in disease biology. Future research should focus on identifying early biomarkers of proteostasis imbalance …

9. Targeting Amyloid Beta Aggregation and Neuroinflammation in Alzheimer’s Disease: Advances and Future DirectionsResearch summary

   Research summaries · alzhub.org/study/targeting-amyloid-beta-aggregation-and-neuroinflammation-in-41677657

   … interlinked mechanisms driving disease progression. This review focuses specifically on these two processes and highlights current pharmacological limitations in modifying disease pathology. Natural products such as curcumin, …

10. The Effectiveness of Palliative Care Interventions in Long-Term Care Facilities: A Systematic ReviewResearch summary

    Research summaries · alzhub.org/study/the-effectiveness-of-palliative-care-interventions-in-long-term-care-39063954

    The increasing elderly population is driving higher utilization rates of long-term care facilities, where residents often have multiple chronic diseases, making them potential candidates for palliative care. Timely palliative …

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