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290 results for "driving".

Research summaries 267

Showing the best 200 of 267, 161–170, page 17 of 20. Filter these by subject, year and score in the research library →

1. Addressing the ethical, policy, and social challenges of preclinical Alzheimer diseaseResearch summary

   Research summaries · alzhub.org/study/addressing-the-ethical-policy-and-social-challenges-of-preclinical-21917767

   … practices governing driving, financial management and planning, and privacy and confidentiality. Research suggests that Alzheimer disease (AD) pathophysiology begins prior to the clinical expression of the disease and that …

2. ApoE in Alzheimer's disease: pathophysiology and therapeutic strategiesResearch summary

   Research summaries · alzhub.org/study/apoe-in-alzheimer-s-disease-pathophysiology-and-therapeutic-strategies-36348357

   … the brain with apoE4 driving earlier and more abundant amyloids. ApoE isoforms also have differential effects on multiple Aβ-related or Aβ-independent pathways. The complexity of apoE biology and pathobiology presents challenges …

3. ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s diseaseResearch summary

   Research summaries · alzhub.org/study/apoe-calypse-tau-apoetau-synergy-in-alzheimers-disease-40856646

   … molecular mechanisms driving AD and primary tauopathies. This review summarizes evidence that APOE ε4 worsens tau-mediated neurodegeneration and tau-related pathology, in addition to promoting amyloid deposition. It suggests the …

4. Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and MetabolomeResearch summary

   Research summaries · alzhub.org/study/apolipoprotein-e4-and-insulin-resistance-interact-to-impair-cognition-28272510

   … appear to interact in driving cognitive dysfunction. However, shared mechanisms that could explain their overlapping pathophysiology have yet to be found. We hypothesized that, compared to E3 mice, E4 mice would be more …

5. Artificial Intelligence in Health Care: Bibliometric AnalysisResearch summary

   Research summaries · alzhub.org/study/artificial-intelligence-in-health-care-bibliometric-analysis-32723713

   Background As a critical driving power to promote health care, the health care-related artificial intelligence (AI) literature is growing rapidly. Objective The purpose of this analysis is to provide a dynamic and longitudinal …

6. Artificial intelligence for medicine 2025: Navigating the endless frontierResearch summary

   Research summaries · alzhub.org/study/artificial-intelligence-for-medicine-2025-navigating-the-endless-ae477775

   Artificial intelligence (AI) is driving transformative changes in the field of medicine, with its successful application relying on accurate data and rigorous quality standards. By integrating clinical information, pathology, …

7. Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disordersResearch summary

   Research summaries · alzhub.org/study/astrocyte-contribution-to-dysfunction-risk-and-progression-in-36316501

   … function, and may suggest a driving role for astrocytes in disease initiation, is discussed. A summary of how astrocyte transcriptomic and proteomic signatures are altered during the progression of neurodegenerative disorders …

8. Brain-wide Cerebrospinal Fluid Recirculation Collapse in Alzheimer’s DiseaseResearch summary

   Research summaries · alzhub.org/study/brain-wide-cerebrospinal-fluid-recirculation-collapse-in-alzheimers-a92521b4

   … the precise mechanisms driving their profound failure in Alzheimer’s disease (AD) remain largely elusive. Here, we reveal that macroscopic CSF propagates dorsally via the perivascular spaces (PAS) of major ventral arteries—the …

9. Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tauResearch summary

   Research summaries · alzhub.org/study/cell-autonomous-microglia-defects-in-a-stem-cell-model-of-40527900

   … cells like microglia in driving disease pathophysiology. Here, we demonstrate that MAPT mRNA and tau protein are expressed in microglia in human brains and in human induced pluripotent stem cell (iPSC)-derived microglia like …

10. Characterization of hydrophobic residue requirements for alpha-synuclein fibrillizationResearch summary

    Research summaries · alzhub.org/study/characterization-of-hydrophobic-residue-requirements-for-alpha-19722699

    … hydrophobic residues in driving the intrinsic ability of alpha-synuclein to polymerize. Several small deletions, even one with as few as two amino acid residues (A76 and V77), dramatically impaired the ability of alpha-synuclein …

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