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290 results for "driving".

Research summaries 267

Showing the best 200 of 267, 141–150, page 15 of 20. Filter these by subject, year and score in the research library →

1. Frontal white matter lesions in Alzheimer's disease are associated with both small vessel disease and AD-associated cortical pathologyResearch summary

   Research summaries · alzhub.org/study/frontal-white-matter-lesions-in-alzheimer-s-disease-are-associated-34608542

   … degenerative mechanism driving posterior white matter disruption, and both AD-associated degenerative and vascular mechanisms contributed to anterior matter disruption. In this pilot study, we used human post-mortem brain tissue …

2. Gamma frequency entrainment attenuates amyloid load and modifies microgliaResearch summary

   Research summaries · alzhub.org/study/gamma-frequency-entrainment-attenuates-amyloid-load-and-modifies-27929004

   … disease. Optogenetically driving fast-spiking parvalbumin-positive (FS-PV)-interneurons at gamma (40 Hz), but not other frequencies, reduces levels of amyloid-β (Aβ) 1-40 and Aβ 1-42 isoforms. Gene expression profiling revealed …

3. Hypoglycaemia in diabetes mellitus: epidemiology and clinical implicationsResearch summary

   Research summaries · alzhub.org/study/hypoglycaemia-in-diabetes-mellitus-epidemiology-and-clinical-25287289

   … everyday activities such as driving, work performance and leisure pursuits. In addition to accidents and physical injury, the morbidity of hypoglycaemia involves the cardiovascular and central nervous systems. Whereas coma and …

4. Inflammation and cerebral small vessel disease: A systematic reviewResearch summary

   Research summaries · alzhub.org/study/inflammation-and-cerebral-small-vessel-disease-a-systematic-review-31181331

   … blood-brain barrier may be a driving force behind SVD. Conversely, cross-sectional findings on systemic inflammation were mixed, although longitudinal investigations demonstrated that elevated levels of systemic inflammatory …

5. Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 yearsResearch summary

   Research summaries · alzhub.org/study/inflammation-anti-inflammatory-agents-and-alzheimer-disease-the-last-16914866

   … into inflammation as a driving force in the pathology of Alzheimer disease (AD). The first was the identification of activated microglia in association with the lesions. The second was the finding that rheumatoid arthritics were …

6. Interferon γ: a master cytokine in microglia-mediated neural network dysfunction and neurodegenerationResearch summary

   Research summaries · alzhub.org/study/interferon-a-master-cytokine-in-microglia-mediated-neural-network-36283867

   … IFN-γ is pivotal for driving Toll-like receptor (TLR)-activated microglia into neurotoxic phenotypes that induce energetic and oxidative stress, severe network dysfunction, and neuronal death. Pharmacological targeting of …

7. Lecanemab: Wirksamkeit beruht auf dem Fc-Fragment des AntikörpersResearch summary

   Research summaries · alzhub.org/study/lecanemab-wirksamkeit-beruht-auf-dem-fc-fragment-des-antikorpers-0681bd63

   … investigate the mechanisms driving antibody-induced amyloid clearance, so the work is preclinical. Lecanemab ist eine Anti-Amyloid-Antikörper-Therapie, die entwickelt wurde, um toxische Amyloid-Plaques zu beseitigen und das …

8. Maternally inherited mitochondrial myopathy and myoclonic epilepsyResearch summary

   Research summaries · alzhub.org/study/maternally-inherited-mitochondrial-myopathy-and-myoclonic-epilepsy-3922281

   … by prominent photic driving seen on electroencephalograms and high-amplitude visual and somatosensory evoked responses but no myoclonus, ataxia, or dementia. The individual clinical features of the disease worsen over time for …

9. Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?Research summary

   Research summaries · alzhub.org/study/mitochondrial-imbalance-in-down-syndrome-a-driver-of-accelerated-40249934

   … neuronal vulnerability, driving cognitive decline and neurodegeneration. This review examines the genetic and biochemical underpinnings of mitochondrial dysfunction in DS, with a focus on the role of HSA21-encoded genes. We also …

10. Neuroplasticity and Clinical Practice: Building Brain Power for HealthResearch summary

    Research summaries · alzhub.org/study/neuroplasticity-and-clinical-practice-building-brain-power-for-health-27507957

    The focus of this review is on driving neuroplasticity in a positive direction using evidence-based interventions that also have the potential to improve general health. One goal is to provide an overview of the many ways new …

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