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287 results for "driving".

Research summaries 264

Showing the best 200 of 264, 131–140, page 14 of 20. Filter these by subject, year and score in the research library →

1. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathyResearch summary

   Research summaries · alzhub.org/study/aberrant-deposition-of-stress-granule-resident-proteins-linked-to-30767771

   … key disease mechanism driving TDP-43 proteinopathy in c9FTD/ALS. Results Relative to control mice, gliosis and neurodegeneration accompanied by cognitive and motor deficits were observed in (G 4 C 2 ) 149 mice by 6 months of …

2. Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/amyloid-a-immunotherapy-induced-microhemorrhages-are-linked-to-39434125

   … and vascular damage in driving the development of microhemorrhage. Conclusions In summary, our study has established a significant link between CAA-Aβ antibody immune complex formation, immune activation and vascular damage …

3. Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancerResearch summary

   Research summaries · alzhub.org/study/apolipoprotein-e-induces-pathogenic-senescent-like-myeloid-cells-in-36868226

   … subset of myeloid cells driving immune suppression, tumor proliferation, and treatment resistance. Physiologically, neutrophils are known to have a short half-life. Here, we report the identification of a subset of neutrophils …

4. Bacteroides fragilis Lipopolysaccharide and Inflammatory Signaling in Alzheimer's DiseaseResearch summary

   Research summaries · alzhub.org/study/bacteroides-fragilis-lipopolysaccharide-and-inflammatory-signaling-in-27725817

   … factors, such as BF-LPS, in driving pro-inflammatory degenerative neuropathology in the AD brain. The deleterious effects of these bacterial exudates appear to become more important as GI tract and blood-brain barriers alter or …

5. Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing MiceResearch summary

   Research summaries · alzhub.org/study/calcineurin-nfat-signaling-in-activated-astrocytes-drives-network-28559377

   … pathologic mechanism for driving glutamate dysregulation and neuronal hyperactivity during AD. SIGNIFICANCE STATEMENT Neuronal hyperexcitability and excitotoxicity are increasingly recognized as important mechanisms for …

6. Cryo-ET and Sub-Volume Analysis of Fibrillar Pathology in the Neurodegenerative Human BrainResearch summary

   Research summaries · alzhub.org/study/cryo-et-and-sub-volume-analysis-of-fibrillar-pathology-in-the-b5f4b141

   … However, the mechanisms driving distinct polymorphs remain unclear because no method currently links the cellular context, composition and ultrastructure of individual aggregates to their constituent fibril polymorphs. Here, we …

7. Does inflammatory bowel disease play a role in cognitive decline? A systematic reviewResearch summary

   Research summaries · alzhub.org/study/does-inflammatory-bowel-disease-play-a-role-in-cognitive-decline-a-42172661

   … underlying mechanisms driving this association remain poorly understood and population, clinical and experimental studies show controversial results. Among others, factors such as chronic inflammation, gut-brain axis dysfunction, …

8. Endogenous TDP-43 localized to stress granules can subsequently form protein aggregatesResearch summary

   Research summaries · alzhub.org/study/endogenous-tdp-43-localized-to-stress-granules-can-subsequently-form-22306778

   … cellular mechanisms driving the abnormal accumulation of TDP-43 are not understood, recent studies have shown that an early change to TDP-43 metabolism in disease may be accumulation in cytosolic RNA stress granules (SGs). …

9. Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal SyndromeResearch summary

   Research summaries · alzhub.org/study/evaluation-of-plasma-phosphorylated-tau217-for-differentiation-37010841

   … have revealed AD is the driving neuropathology in up to 40% of cases. This differentiates CBS from other 4-repeat tauopathy (4RT)-associated syndromes, such as progressive supranuclear palsy Richardson syndrome (PSP-RS) and …

10. Excessive daytime sleepiness and sudden-onset sleep in Parkinson disease: a survey by the Canadian Movement Disorders GroupResearch summary

    Research summaries · alzhub.org/study/excessive-daytime-sleepiness-and-sudden-onset-sleep-in-parkinson-11798367

    … concerns sleepiness and driving safety in Parkinson's disease and does not address treating, curing, or preventing Alzheimer's disease. Results Excessive daytime sleepiness was present overall in 327 (51%) of the 638 patients …

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