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287 results for "driving".

Research summaries 264

Showing the best 200 of 264, 101–110, page 11 of 20. Filter these by subject, year and score in the research library →

1. C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC ‐Derived Microglia and Modulates Glial‐Neuronal CrosstalkResearch summary

   Research summaries · alzhub.org/study/c9orf72-repeat-expansion-induces-metabolic-dysfunction-in-human-ipsc-40888599

   … role of microglia in driving metabolic dysregulation and intercellular crosstalk in ALS pathogenesis and suggest that targeting metabolic pathways in immune cells may provide new therapeutic avenues. In cell models from C9orf72 …

2. Cognitive Intra-individual Variability in HIV: an Integrative ReviewResearch summary

   Research summaries · alzhub.org/study/cognitive-intra-individual-variability-in-hiv-an-integrative-review-34826006

   … everyday functioning (i.e., driving simulation performance), specifically medication adherence, and 4) even mortality. This inspires future directions for research. First, greater cognitive intraindividual variability may reflect …

3. Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer’s DiseaseResearch summary

   Research summaries · alzhub.org/study/computational-approaches-for-supporting-combination-therapy-in-the-80f66de5

   … informed neuronal circuits driving functional clinical readouts. Informed by data-driven approaches this knowledge-driven modeling could systematically and quantitatively simulate all possible target combinations for a maximal …

4. Depression and dementia: interrogating the causality of the relationshipResearch summary

   Research summaries · alzhub.org/study/depression-and-dementia-interrogating-the-causality-of-the-39798961

   … evidence of both mechanisms driving the association. This study found depression was strongly linked to later dementia, but concludes the relationship is largely due to reverse causation, meaning brain changes from dementia may …

5. Dysregulation of a novel autophagosome-mitochondria contact contributes to tauopathy-related neurodegeneration by disrupting autophagyResearch summary

   Research summaries · alzhub.org/study/dysregulation-of-a-novel-autophagosome-mitochondria-contact-42316849

   … a critical mechanism driving autophagy dysfunction and pathological MAPT/tau buildup in tauopathy neurons and highlight TBC1D15-modulated AV-Mito contact release and autophagy as promising therapeutic targets for tauopathies, …

6. Environment, lifestyle, and cancer in womenResearch summary

   Research summaries · alzhub.org/study/environment-lifestyle-and-cancer-in-women-40277318

   … factors, with obesity driving hormonal disruptions and systemic inflammation. Physical inactivity and diets rich in animal fats increase the risk of endometrial cancer, along with air pollution and microbiome imbalances …

7. Genetic and epigenetic targets of natural dietary compounds as anti-Alzheimer's agentsResearch summary

   Research summaries · alzhub.org/study/genetic-and-epigenetic-targets-of-natural-dietary-compounds-as-anti-37843220

   … pathophysiological mechanisms driving Alzheimer's disease are interfaced with epigenetic dysregulation. However, the dynamic nature of epigenetics seems to open up new avenues and hope in regenerative neurogenesis to improve …

8. Genome‐Wide Analysis of Memory, Language, and Executive Function Reveals Domain‐Specific Genetic Architecture in Alzheimer DiseaseResearch summary

   Research summaries · alzhub.org/study/genomewide-analysis-of-memory-language-and-executive-function-reveals-41442684

   … the distinct processes driving deficits in memory, language, and executive function. Such insights pave the way for more precise, syndrome-focused interventions, ultimately guiding a precision medicine approach tailored to the …

9. Gut microbiome-targeted therapies for Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/gut-microbiome-targeted-therapies-for-alzheimer-s-disease-37934614

   … of gut microbiota in driving AD progression, and the successes and challenges of implementing available gut microbiome-targeted therapies (including probiotics, prebiotics, synbiotics, postbiotics, and fecal microbiota …

10. High-Content Screening Identifies Dithiocarbamates As A Class Of Chemicals That Disrupts TDP-43 ProteostasisResearch summary

    Research summaries · alzhub.org/study/high-content-screening-identifies-dithiocarbamates-as-a-class-of-76961fd3

    … multiple hit mechanism driving TDP-43 dysfunction. Together, these findings identify DTCs, particularly those used as agricultural pesticides, as dominant modifiers of TDP-43 proteostasis and identify redox imbalance and zinc …

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