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287 results for "driving".

Research summaries 264

Showing the best 200 of 264, 91–100, page 10 of 20. Filter these by subject, year and score in the research library →

1. The role of reduced fitness to drive due to medical impairments in explaining crashes involving older driversResearch summary

   Research summaries · alzhub.org/study/the-role-of-reduced-fitness-to-drive-due-to-medical-impairments-in-18696384

   … conditions that may affect driving can serve as "red flags" to assist health care professionals and driving administrators to identify drivers who may need further evaluation. Conclusions Medical conditions overall, do impact the …

2. Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's diseaseResearch summary

   Research summaries · alzhub.org/study/tumor-necrosis-factor-synthesis-inhibitor-3-6-dithiothalidomide-22642825

   … neuroinflammation is the driving force behind these disorders, compelling evidence implicates its role in exacerbating disease progression, with a key player being the potent proinflammatory cytokine TNF-α. Elevated TNF-α levels …

3. Vascular Considerations for Amyloid ImmunotherapyResearch summary

   Research summaries · alzhub.org/study/vascular-considerations-for-amyloid-immunotherapy-36269539

   … 2000s, and the mechanisms driving it are still unknown. Recent approval of aducanumab comes with renewed urgency to consider vascular deficits caused by anti-Aβ immunotherapy. This article reviews the history of anti-Aβ …

4. Visual dysfunction in dementia with Lewy bodiesResearch summary

   Research summaries · alzhub.org/study/visual-dysfunction-in-dementia-with-lewy-bodies-38907811

   … visual hallucinations, driving impairment, falls, and other negative outcomes. While visual dysfunction in clinically manifest DLB is well recognized, recent work has focused on prodromal or mild cognitive impairment (MCI) due …

5. Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trialResearch summary

   Research summaries · alzhub.org/study/aerobic-exercise-for-alzheimer-s-disease-a-randomized-controlled-28187125

   … may be important in driving brain benefits. Trial registration ClinicalTrials.gov NCT01128361. Aerobic exercise was associated with a modest gain in functional ability (Disability Assessment for Dementia) compared to individuals …

6. Affective Computing for Late-Life Mood and Cognitive DisordersResearch summary

   Research summaries · alzhub.org/study/affective-computing-for-late-life-mood-and-cognitive-disorders-35002802

   … vocal biomarkers, and driving and behavior can provide objective biomarkers for early identification and monitoring, allow more comprehensive understanding of daily life and disease fluctuations, and facilitate an understanding …

7. Alzheimer's disease beyond amyloid: Can the repetitive failures of amyloid-targeted therapeutics inform future approaches to dementia drug discovery?Research summary

   Research summaries · alzhub.org/study/alzheimer-s-disease-beyond-amyloid-can-the-repetitive-failures-of-32247851

   … dementia targets are driving research in new directions bolstered by recent findings on the genetic, omics and systems biology associated with AD/dementia. In moving forward, lessons learnt from the amyloid debacle should be used …

8. Amyloid-β and Tau at the Crossroads of Alzheimer's DiseaseResearch summary

   Research summaries · alzhub.org/study/amyloid-and-tau-at-the-crossroads-of-alzheimer-s-disease-32096039

   … amyloid-β is the predominant driving factor in AD development. Nonetheless, more recent advances in imaging analysis, biomarkers and mouse models are now redefining this original hypothesis, as it is likely amyloid-β, tau and …

9. Amyloid-β, Tau Protein, α-Synuclein, TDP-43, and FUS in Mixed Pathology: And Intrinsic Disorder to Rule Them AllResearch summary

   Research summaries · alzhub.org/study/amyloid-tau-protein-synuclein-tdp-43-and-fus-in-mixed-pathology-and-42074305

   … proteins, (2) mechanisms driving mixed neuropathology, (3) therapeutic implications of disorder-driven interactions, and (4) key unresolved questions shaping future research. By framing neurodegeneration as a network of …

10. Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategiesResearch summary

    Research summaries · alzhub.org/study/apolipoprotein-e-and-alzheimer-disease-pathobiology-and-targeting-31367008

    … the risk of AD is by driving earlier and more abundant amyloid pathology in the brains of APOE*ε4 carriers. The number of amyloid-β (Aβ)-dependent and Aβ-independent pathways that are known to be differentially modulated by APOE …

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