Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Every row

Showing 3 of 382 rows. One row per study per exposure: a study that tested two different things appears twice, once for each.

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Research and outcomes, 3 rows. Every row links to its source.
Exposure Question Direction Outcome measured Design People Effect size, as the source reported it Source
Amyloid and tau PET (appropriate use criteria) Care, carers and services Treatment No direction reported
why

Appropriate use criteria rated by consensus: for amyloid PET seven of 17 scenarios were rated appropriate, two uncertain and eight rarely appropriate; for tau PET five, six and six. No effect estimate is reported.

None measured (appropriate use criteria) systematic review not stated not established — consensus criteria; the abstract reports scenario ratings, not an effect estimate. Alzheimer's & Dementia 2025
✓ Peer-reviewed PMID 39776249
Blood biomarker test (p-tau217 / amyloid ratio) Care, carers and services Treatment No direction reported
why

A clinical practice guideline. It sets performance thresholds for blood tests (at least 90% sensitivity and 75% specificity for triage; at least 90% for both to substitute for amyloid PET or CSF) and reports no effect estimate of its own.

None measured (clinical practice guideline) systematic review not stated not established — guideline; recommendations rather than an effect estimate. Alzheimer's & Dementia 2025
✓ Peer-reviewed PMID 40729527
Diagnostic evaluation and disclosure guideline Care, carers and services Treatment No direction reported
why

A clinical practice guideline. It sets out a structured, patient-centred process for evaluating, diagnosing and disclosing suspected Alzheimer's disease or related dementias in any practice setting, and reports no effect estimate.

None measured (clinical practice guideline for primary care) systematic review not stated not established — guideline; the abstract reports no effect estimate. Alzheimer's & Dementia 2024
✓ Peer-reviewed PMID 39713942

How this table was built, and where it is weak →