Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Every row

Showing 1 of 382 rows. One row per study per exposure: a study that tested two different things appears twice, once for each.

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Research and outcomes, 1 row. Every row links to its source.
Exposure Question Direction Outcome measured Design People Effect size, as the source reported it Source
Anti-amyloid antibody Medicines Treatment Mixed
why

Two identically designed trials disagreed: EMERGE met its primary endpoint, ENGAGE did not.

CDR-SB at 78 weeks phase 3 trial 3,285 EMERGE: CDR-SB difference -0.39 vs. placebo (95% CI -0.69 to -0.09; P=.012); ENGAGE: CDR-SB difference +0.03 vs. placebo (95% CI -0.26 to 0.33; P=.833) Journal of Prevention of Alzheimer's Disease 2022
✓ Peer-reviewed PMID 35542991

How this table was built, and where it is weak →