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Home › Research › What the research found › Every row

Every row of the evidence table

One row per finding: what was tested, which way the result went, and how the study was built. The answer by area, and where the studies disagree, are on the main page.

Every row

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Area All 382 Care, carers and services 140 Medicines 85 Genes (not modifiable) 35 All modifiable factors together 27 Diet and supplements 23 Exercise and activity 21 Sleep, mood and social life 19 Hearing and vision 8 Alcohol, tobacco and cannabis 6 Infection and vaccination 5 Heart and metabolic health 4 Injury, delirium and falls 4 Environment 3 Cognitive activity 2
Question Both Prevention 190 Treatment 192
Direction Any Benefit 144 Harm 105 No effect 38 Mixed 37 No direction reported 58
Design Any meta-analysis 57 randomised trial 44 phase 3 trial 15 systematic review 9 phase 2 trial 10 cohort study 136 phase 1 trial 2 cross-sectional study 31 case-control study 14 modelling study 20 regulatory decision 7 company announcement 1 coverage determination 1 None 35
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Showing 3 of 382 rows. One row per study per exposure: a study that tested two different things appears twice, once for each.

Scroll the table sideways to see every column.

Research and outcomes, 3 rows. Every row links to its source.
Exposure Question Direction Outcome measured Design People Effect size, as the source reported it Source
Anti-amyloid antibody Medicines Treatment Benefit
why

Phase Ib/IIa biomarker result in 13 people; no cognitive outcome measured.

 Amyloid PET and CSF biomarkers (surrogate) phase 2 trial 13 3.6 mg/kg cohort: "-89 centiloids after 12 weeks (n=13), and -107 centiloids after 28 weeks (n=12)" on amyloid PET; at week 25 CSF "total tau, phosphorylated tau181, and neurogranin were reduced by 30%, 34%, and 29%, respectively" Alzheimer's & Dementia (AAIC 2025 conference abstract) 2025
⚠ Conference abstract — not peer-reviewed PMC12740797
Psychotropics for agitation / psychosis Medicines Treatment Benefit
why

The NPI-C agitation/aggression measure did not reach significance (p=0.094).

 Pittsburgh Agitation Scale over 3 weeks phase 2 trial 75 PAS decline difference -0.74/week (p=0.015, ES 0.53); NPI-C A/A -1.26/week (p=0.094, ES 0.36) The American Journal of Geriatric Psychiatry 2026
✓ Peer-reviewed PMID 41350162
Psychotropics for agitation / psychosis Medicines Treatment Benefit
why

The authors describe the reduction as small (-1.32 points).

 NPI apathy score at 6 weeks phase 2 trial 94 NPI apathy change -1.32 points (95% CI -2.43 to -0.21) vs placebo The Lancet Neurology 2025
✓ Peer-reviewed PMID 39862881

How this table was built, and where it is weak →