alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › What the research found › Every row

Every row of the evidence table

One row per finding: what was tested, which way the result went, and how the study was built. The answer by area, and where the studies disagree, are on the main page.

Every row

Filter

Area All 382 Care, carers and services 140 Medicines 85 Genes (not modifiable) 35 All modifiable factors together 27 Diet and supplements 23 Exercise and activity 21 Sleep, mood and social life 19 Hearing and vision 8 Alcohol, tobacco and cannabis 6 Infection and vaccination 5 Heart and metabolic health 4 Injury, delirium and falls 4 Environment 3 Cognitive activity 2
Question Both Prevention 190 Treatment 192
Direction Any Benefit 144 Harm 105 No effect 38 Mixed 37 No direction reported 58
Design Any meta-analysis 57 randomised trial 44 phase 3 trial 15 systematic review 9 phase 2 trial 10 cohort study 136 phase 1 trial 2 cross-sectional study 31 case-control study 14 modelling study 20 regulatory decision 7 company announcement 1 coverage determination 1 None 35
Clear all

Showing 3 of 382 rows. One row per study per exposure: a study that tested two different things appears twice, once for each.

Scroll the table sideways to see every column.

Research and outcomes, 3 rows. Every row links to its source.
Exposure Question Direction Outcome measured Design People Effect size, as the source reported it Source
Anti-amyloid antibody Medicines Treatment Benefit
why

Phase 1 dose-finding. The outcome is amyloid clearance; no cognitive outcome was measured.

 Amyloid PET clearance (surrogate) randomised trial 41 "On 2,800 mg, every participant dropped below the amyloid positivity threshold within three months"; "After six months, plaque was dose-dependently reduced in all cohorts" Presented at AD/PD 2023 Conference (Gothenburg, Sweden); covered by ALZFORUM and NeurologyLive 2023
⚠ Conference abstract — not peer-reviewed no DOI or PMID exists
Antihypertensives / BP lowering Medicines Prevention Benefit
why

Significant for MCI and for the MCI-or-dementia composite; not significant for probable dementia alone (HR 0.86, 95% CI 0.72-1.02).

 MCI and probable dementia over median 7 years randomised trial 9,361 Probable dementia: 8.5 vs. 10.2 per 1,000 person-years (HR 0.86, 95% CI 0.72-1.02); MCI: HR 0.87 (95% CI 0.76-1.00); composite MCI-or-dementia: HR 0.89 (95% CI 0.79-0.99) Neurology 2025
✓ Peer-reviewed PMID 39819096
Antihypertensives / BP lowering Medicines Prevention Benefit
why

A large drop in blood pressure (22/9 mmHg) and fewer serious adverse events in the intervention villages.

 All-cause dementia over 48 months randomised trial 33,995 All-cause dementia RR 0.85 (95% CI 0.76-0.95) Nature Medicine 2025
✓ Peer-reviewed PMID 40258956

How this table was built, and where it is weak →