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Home › Research › What the research found › Every row

Every row of the evidence table

One row per finding: what was tested, which way the result went, and how the study was built. The answer by area, and where the studies disagree, are on the main page.

Every row

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Area All 382 Care, carers and services 140 Medicines 85 Genes (not modifiable) 35 All modifiable factors together 27 Diet and supplements 23 Exercise and activity 21 Sleep, mood and social life 19 Hearing and vision 8 Alcohol, tobacco and cannabis 6 Infection and vaccination 5 Heart and metabolic health 4 Injury, delirium and falls 4 Environment 3 Cognitive activity 2
Question Both Prevention 190 Treatment 192
Direction Any Benefit 144 Harm 105 No effect 38 Mixed 37 No direction reported 58
Design Any meta-analysis 57 randomised trial 44 phase 3 trial 15 systematic review 9 phase 2 trial 10 cohort study 136 phase 1 trial 2 cross-sectional study 31 case-control study 14 modelling study 20 regulatory decision 7 company announcement 1 coverage determination 1 None 35
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Showing 1 of 382 rows for Gene therapy delivering APOE2 / APOE2-Christchurch (preclinical). One row per study per exposure: a study that tested two different things appears twice, once for each.

Scroll the table sideways to see every column.

Research and outcomes, 1 row. Every row links to its source.
Exposure Question Direction Outcome measured Design People Effect size, as the source reported it Source
Gene therapy delivering APOE2 / APOE2-Christchurch (preclinical) Medicines Treatment Benefit
why

Direction is for AAVrh.10 delivery of APOE2 with the Christchurch mutation in mice: both vectors suppressed amyloid, but only the Christchurch variant also suppressed tau tangles and glial activation in tau mice and outperformed plain APOE2 behaviourally. Mouse work with no human outcome.

 Amyloid and tau pathology, glial activation and behaviour in APOE4-humanised mouse models None not stated not established — pubmed abstract reports no numeric effect size. Molecular Therapy 2024
✓ Peer-reviewed PMID 39511891

How this table was built, and where it is weak →