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Area All 382 Care, carers and services 140 Medicines 85 Genes (not modifiable) 35 All modifiable factors together 27 Diet and supplements 23 Exercise and activity 21 Sleep, mood and social life 19 Hearing and vision 8 Alcohol, tobacco and cannabis 6 Infection and vaccination 5 Heart and metabolic health 4 Injury, delirium and falls 4 Environment 3 Cognitive activity 2

Question Both Prevention 190 Treatment 192

Direction Any Benefit 144 Harm 105 No effect 38 Mixed 37 No direction reported 58

Design Any meta-analysis 57 randomised trial 44 phase 3 trial 15 systematic review 9 phase 2 trial 10 cohort study 136 phase 1 trial 2 cross-sectional study 31 case-control study 14 modelling study 20 regulatory decision 7 company announcement 1 coverage determination 1 None 35

Showing 5 of 382 rows for Anti-tau therapy. One row per study per exposure: a study that tested two different things appears twice, once for each.

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Research and outcomes, 5 rows. Every row links to its source.
Exposure	Question	Direction	Outcome measured	Design	People	Effect size, as the source reported it	Source
Anti-tau therapy Medicines	Treatment	No effect why Co-primary endpoints were not met at 52 weeks. The comparator was a low dose of the same drug rather than placebo, which the authors say masked any separation; they report separation in the MCI subgroup only at 78 and 104 weeks.	ADAS-cog11 and ADCS-ADL23 at 52 weeks (co-primary)	phase 3 trial	598	"It was not possible to demonstrate significant differences on the co-primary clinical endpoints (ADAS-cog11 and ADCS-ADL23) at 52 weeks due to symptomatic activity in the control arm." In MCI, ADAS-cog13 differences between early- and delayed-start HMTM 16 mg/day reached p=0.0291 at 78 weeks and p=0.0308 at 104 weeks; NfL progression fell (p=0.0291) and tau pathology (p-tau217) fell (p=0.0165) in MCI	The Journal of Prevention of Alzheimer's Disease 2026 ✓ Peer-reviewed PMID 41570392
Anti-tau therapy Medicines	Treatment	No effect why The primary endpoint was not met: the low dose showed no clinically meaningful benefit and the 3 mg dose showed 32% greater progression than placebo, with more serious adverse events. Less whole-brain volume loss on MRI is a surrogate finding.	iADRS disease-progression ratio at 100 weeks (primary); tau PET, brain volume, adverse events	phase 2 trial	327	The disease progression ratio relative to placebo was 0.84 (95% credible interval [CrI], 0.66-1.04) for the ceperognastat 0.75 mg group and 1.32 (CrI, 1.10-1.58) for the ceperognastat 3 mg group, corresponding to 16% less and 32% greater progression, respectively. No benefits were demonstrated for secondary clinical end points	JAMA 2026 ✓ Peer-reviewed PMID 42441396
Anti-tau therapy Medicines	Treatment	No effect why The primary clinical endpoint (CDR-SB) was not met in the overall population. The tau figures are a biomarker outcome, not a clinical one.	CDR-SB (primary); tau PET accumulation	phase 2 trial	466	"Slowed the rate of tau accumulation versus placebo in key brain regions by 33%-58%" overall and "by 63%-67%" in the low-tau or APOE4 non-carrier subgroup; "In the overall study population, no beneficial effect of low- or high-dose bepranemab compared with placebo was observed on the primary endpoint"; ADAS-Cog14 decline slowed 21-25%	UCB press release (data presented at CTAD 2024) 2024 ⚠ Press release — not a study no DOI or PMID exists
Anti-tau therapy Medicines	Treatment	No effect why ADAS-Cog11 showed slower decline, but the co-primary functional endpoint (ADCS-ADL) did not differ and the authors classify the study as negative.	ADCS-ADL and ADAS-Cog11 (co-primary) at week 49	phase 2 trial	272	"At week 49, the semorinemab arm demonstrated a 42.2% reduction (-2.89 points, 95% CI -4.56 to -1.21, p = 0.0008) in decline on the ADAS-Cog11 (coprimary endpoint) relative to the placebo arm"; ADCS-ADL difference -0.83 points (95% CI -3.39 to 1.72, p = 0.52), with no difference on MMSE or CDR-SB	Neurology 2023 ✓ Peer-reviewed PMID 37643887
Anti-tau therapy Medicines	Treatment	Benefit why Phase 1b safety and target-engagement result: adverse events were all mild or moderate with no serious events on MAPTRx, and CSF total tau fell dose-dependently by more than 50% in the two highest-dose groups. No clinical outcome was measured.	Safety (primary) and CSF total tau (exploratory target engagement) in mild Alzheimer's disease	phase 1 trial	46	Adverse events were reported in 94% of MAPTRx-treated patients and 75% of placebo-treated patients; all were mild or moderate. No serious adverse events were reported in MAPTRx-treated patients. Dose-dependent reduction in the CSF total-tau concentration was observed with greater than 50% mean reduction from baseline at 24 weeks post-last dose in the 60 mg (four doses) and 115 mg (two doses) MAPTRx groups	Nature Medicine 2023 ✓ Peer-reviewed PMID 37095250

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