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Home › Research › What the research found › Every row

Every row of the evidence table

One row per finding: what was tested, which way the result went, and how the study was built. The answer by area, and where the studies disagree, are on the main page.

Every row

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Area All 382 Care, carers and services 140 Medicines 85 Genes (not modifiable) 35 All modifiable factors together 27 Diet and supplements 23 Exercise and activity 21 Sleep, mood and social life 19 Hearing and vision 8 Alcohol, tobacco and cannabis 6 Infection and vaccination 5 Heart and metabolic health 4 Injury, delirium and falls 4 Environment 3 Cognitive activity 2
Question Both Prevention 190 Treatment 192
Direction Any Benefit 144 Harm 105 No effect 38 Mixed 37 No direction reported 58
Design Any meta-analysis 57 randomised trial 44 phase 3 trial 15 systematic review 9 phase 2 trial 10 cohort study 136 phase 1 trial 2 cross-sectional study 31 case-control study 14 modelling study 20 regulatory decision 7 company announcement 1 coverage determination 1 None 35
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Showing 2 of 382 rows for TREM2 variants. One row per study per exposure: a study that tested two different things appears twice, once for each.

Scroll the table sideways to see every column.

Research and outcomes, 2 rows. Every row links to its source.
Exposure Question Direction Outcome measured Design People Effect size, as the source reported it Source
TREM2 variants Genes (not modifiable) Prevention Harm
why

Direction is for carrying TREM2 T96K: it increased AD risk in family-based and case-control sequencing data and, despite being a gain-of-function variant, impaired microglial clustering around plaques, amyloid uptake and the transition to disease-associated microglia in female 5xFAD mice.

 AD risk in a whole-genome sequencing dataset, and microglial plaque clustering, amyloid uptake and disease-associated transition in female 5xFAD knock-in mice None not stated not established — pubmed abstract reports no numeric effect size (no odds ratio for the risk association is printed). Neuron 2026
✓ Peer-reviewed PMID 41109213
TREM2 variants Genes (not modifiable) Prevention Harm
why

Direction is for carrying the risk variants: R62H and T96K caused excessive skipping of exon 2 and overproduction of a potentially antagonistic TREM2 isoform, and several early-onset dementia variants acted primarily through splicing defects. A molecular mechanism result, not a clinical outcome.

 TREM2 exon 2 skipping and isoform production in variant carriers None not stated not established — pubmed abstract reports no numeric effect size. the library had recorded "1.8-fold increase in exon 2 skipping in r62h carriers", which the abstract… Brain 2024
✓ Peer-reviewed PMID 38226698

How this table was built, and where it is weak →